Il Ginseng è sicuramente il più noto ed efficace
Transcript
Il Ginseng è sicuramente il più noto ed efficace
Ginseng Il Ginseng è sicuramente il più noto ed efficace antistress, capace di riequilibrare l’individuo che si trova in difficoltà fisiche dovute a stanchezza, stress ed affaticamento. La sua azione la si deve a svariati meccanismi: 1. Azione endocrina: I ginsenosidi agiscono riequilibrando l’asse ipotalamo-ipofisi-surrenalico nediante stimolazione dell’ipofisi(aumento della liberazione di ACTH) con conseguente aumento dei corticosteroidi. 2. Aumento della sintesi proteica e della produzione di RNA: dovuti ai ginsenosidi, capaci di stimolare la sintesi di c-GMP,variazioni direttamente proporzionali alla biosintesi proteica cellulare. 3. Miglioramento del rendimento energetico: è stato dimostrato che i panaxani, sono capaci di sensibilizzare il recettore insulinico cellulare all’insulina e conseguentemente stimolare la glicolisi con miglioramento del rendimento energetico e riduzione della glicemia. 4. Stimolazione del S.N.C. e azione sul comportamento: I ginsenosidi sono attivi sul S.N.C.(Rg1 e Rb1), entrambi aumentano la vita media dei neuroni, antrambi aumentano la capacità di apprendimento, e loro attività si compensano. Infatti mentre Rg1 è stimolante sul S.N.C. , ipertensivizzante e aumenta l’intensità e la frequenza dei comportamenti sessuali (afrodisiaco), Rb1 funziona da tranquillante e ipotensivo. 5. Effetti cardiocircolatori: Il ginseng produce effetto inotropo positivo e cronotropo negativo(aumenta la forza di contrazione del muscolo cardiaco e ne rallenta leggermente i battiti). 6. Azione immunostimolante: le frazioni polisaccaridiche, poliiniche e saponosidiche esplicano un reale aumento di tutte le difese immunitarie. Al Ginseng, la moderna farmacologia riconosce una azione tonica e corroborante, confermando l’esperienza millenaria orientale. Il Ginseng è anche particolarmente utile nei pazienti in convalescenza da gravi incidenti, operazioni chirurgiche serie, o malattie debilitanti legati all’età. E’ utile nel sostegno delle malattie a lungo termine, delle debolezze respiratorie, della debolezza sistematica, della funzione cerebrale, per tutte le malattie da deficienza, agendo anche da stimolante, agendo su tutti i sistemi grazie alla sua abilità di aumentare contemporaneamente la tutti i casi di” stanchezza sessuale. 1/7 Ginseng Con il giusto apporto di principio attivo si ritiene quindi che venga stimolato il sistema endocrino pituitario e surrenalico nel rilascio di ormoni stimolanti, capaci di ritardare l’insorgere della fatica. Sempre in sostegno del Ginseng, ulteriori studi sulla qualità del lattato presente nei soggetti sportivi che utilizzavano tale integratore, avrebbero rilevato una minore concentrazione, segno evidente del miglioramento della prestazione aerobica. Al pari della caffeina, il Ginseng favorisce l’ossidazione degli acidi grassi, salvaguardando le scorte di glicogeno epatomuscolare. Per ottenere i migliori benefici, dando credito alle ricerche che esaltano le virtù del Ginseng, occorrerebbe assumere il prodotto per periodi medio-lunghi, in quantità prossime a 200 mg al giorno. (Per maggiore aggiornamento all. scheda tec. N°4)funzione e l’attività in modo rapido. Alla capacità di combattere efficacemente lo stress, si collega infatti la possibilità del Ginseng di intervenire positivamente nella risoluzione di alcuni problemi sessuali, come l’impotenza, la frigidità, la mancanza di desiderio. Un elevato livello di stress, infatti, rappresenta sicuramente uno dei principali fattori che influenzano negativamente, una felice vita sessuale. Se poi, all’accrescimento della capacità di resistenza in situazioni stressanti aggiungiamo l’azione antidepressiva e quelle toniche e rivitalizzanti, appare evidente come il ginseng, pur non essendo una sostanza afrodisiaca favorisca l’ossidazione degli acidi grassi. Asian J Androl. 2009 May;11(3):356-61. Epub 2009 Feb 23. Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction. Kim TH, Jeon SH, Hahn EJ, Paek KY, Park JK, Youn NY, Lee HL. Department of Urology, School of Medicine, Kyung Hee University, Seoul 134-727, Korea. Abstract Korean ginseng and mountain ginseng (Panax ginseng CA Meyer) are important traditional herbal plants whose ginsenosides are generally accepted as serving to improve sexual functions, such as penile erection. We investigated the effects of tissue-cultured mountain ginseng extract (TMGE) on male patients with erectile dysfunction (ED). A double-blind, placebo-controlled study was conducted with 143 patients experiencing ED. Over the course of 8 weeks, one group took 1 000 mg of TMGE twice a day, and the other group took 1,000 mg of placebo twice a day. The effects of the TMGE and the placebo were analyzed using the Korean version of the International Index of Erectile Function (IIEF) questionnaire. A total of 86 patients completed 8 weeks of treatment. The scores on the five domains of the IIEF after medication were significantly higher than the baseline scores in the group treated with TMGE (P<0.05), 2/7 Ginseng whereas no significant improvement was observed in the placebo group (P>0.05). Erectile function and overall satisfaction scores after medication were significantly higher in the TMGE group than in the placebo group (P<0.05). Erectile function of patients in the TMGE-treated group significantly improved, suggesting that TMGE could be utilized for improving erectile function in male patients. J Sex Med. 2010 Jan;7(1 Pt 1):39-49. Epub 2009 Sep 30. Natural aphrodisiacs. Shamloul R. Queen's University-Pharmacology, Kingston, Ontario, Canada. [email protected] Abstract INTRODUCTION: The search for a remedy or a prescription that can enhance sexual function and/or treat male erectile dysfunction has been an obsession throughout known history. Whether it was an Eastern civilization or a Western one, religious or atheist, man's aspiration for a better or best "manhood" has been a history-time goal. AIM: This review will discuss the current research done on the most popular natural aphrodisiacs and examine the weight of evidence to support or discourage the use of any of these substances to enhance sexual desire and/or function. METHODS: Review of the current evidence on the use of natural substances as aphrodisiacs. MAIN OUTCOME MEASURES: Efficacy of natural aphrodisiacs in enhancing sexual function in men and women. RESULTS: There is little evidence from literature to recommend the usage of natural aphrodisiacs for the enhancement of sexual desire and/or performance. Data on yohimbine's efficacy does not support the wide use of the drug, which has only mild effects in the treatment of psychogenic ED. Although there's a positive trend towards recommending ginseng as an effective aphrodisiac, however, more in depth studies involving large number of subjects and its mechanism of action are needed before definite conclusions could be reached. Data on the use of natural aphrodisiacs in women is limited. CONCLUSIONS: The current body of objective evidence does not support the use of any natural aphrodisiac as an effective treatment for male or female sexual dysfunctions. Potent men and men with ED will continue the search for natural aphrodisiacs despite the current disappointing data on their effectiveness. Care should be taken regarding the fraud addition of sildenafil analogues to natural aphrodisiacs. Bibliografia: 1) Bruneton J. Pharmacognosie et phytochimie plantes medicinales. Ed. Lavoisier, Paris, 1993. 2) Sannia A. Formulario pratico di fitoterapia. Ed. Tecniche nuove, Milano, 1994. 3) Yamaguchi H. et al. Analysis of saponins of wild Panax ginseng. Chem Pharm. Bull. 36, 4177-4181, 1988. 4) Seang-Kim H. et al. Antinarcotic effects of the standardized ginseng extract G 115 on morphine. Planta Med. 56, 158-163, 1990. 3/7 Ginseng 5) Itoh T. et al. Effects of Panax ginseng on the vertical and horizontal motor activities and on brain monoamine-related substances in mice. Planta Med. 55, 429-433, 1989. 6) Tsang D. et al. Ginsenoside modulates K+-stimulated noradrenaline release from rat cerebral cortex slices. Planta Med. 266-268, 1986. 7) Tsang D. et al. Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med. 221-224, 1985. 8) Qiu Y. et al. Protective effects of ginsenosides on the learning and memory impairment induced by transient cerebral ischemia-reperfusion in mice. Chin. Pharmacol. Bull. 11, 299-302, 1995. 8B) Pieralisi G. et al. Effect of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals and trace elements on physical performance during exercise. Clin. Ther. 13, 373-382, 1991. 9) Cheng Xiu Juan et al. Effects of ginseng root saponins on central transmitters and plasma corticosterone in cold stress mice and rats. Acta Pharmacol. Sin. 8, 486-489, 1987. 10) McRae S. Elevated serum digoxin levels in a patient taking digoxin and siberian ginseng. Can. Med. Assoc. J. 155, 293-295, 1996. 10B) Sorensen H. et al. A double-masked study of the effects of ginseng on cognitive functions. CURR-THER-RES-CLIN-EXP, 57/12 (959-968), 1996. 11) Janetzky K. et al. Probable interaction between warfarin and ginseng. Am. J. Health Syst. Pharm. 54, 692-693, 1997. 12) Awang D.V.C. Maternal use of ginseng and neonatal androgenization. J. Am. Med. Ass. 266, 363, 1991. 13) Oh K.W. et al. Ginseng total saponin inhibits the dopaminergic depletions induced by methamphetamine. Planta Med. 63, 80-81, 1997. 14) Salvati G. et al. Effects of Panax Ginseng C.A. Meyer saponins on male fertility. Panminerva Med. 38, 249-254, 1996. 15) Han S.W. et al. Ginsenosides stimulate endogenous production of nitric oxide in rat kidney. Int. J. Biochem. Cell. Biol. 28, 573-580, 1996. 16) Choi Y.D. et al. Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle. Int. J. Impot. Res. 10, 37-43, 1998. 17) Kim H.J. et al. The relaxation effects of ginseng saponin in rabbit corporal smooth muscle: is it a nitric oxide donor? Br. J. Urol. 82, 744-748, 1998. 18) Gillis C.N. Panax ginseng pharmacology: a nitric oxide link? Biochem. Pharmacol. 54, 1-8, 1997. 19) Kim W. et al. Panax ginseng protects the testis against 2,3,7, 8-tetrachlorodibenzo-p-dioxin induced testicular damage in guinea pigs. BJU Int. 83, 842-849, 1999. 20) Choi Y.D. et al. In vitro and in vivo experimental effect of Korean red ginseng on erection. J. Urol. 162, 1508-1511, 1999. 21) Nocerino E. et al. The aphrodisiac and adaptogenic properties of ginseng. Fitoterapia 71 Suppl 1, S1-S5, 2000. 21B) Wesnes K.A. et al. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology (Berl) 152, 353-361, 2000. 22) Sannia A. Effetti di un'integrazione fitoterapica, vitaminica e minerale sulla performance sportiva di durata. Acta Phytotherapeutica 2, 15-19, 1996. 23) Avakian E.V. et al. Effect of Panax ginseng extract on energy metabolism during exercise in 4/7 Ginseng rats. Planta Med. 151-154, 1984. 24) Petkov V.D. et al. Effects of standardized extracts GK 501 from Ginkgo biloba, G 115 from Panax ginseng C.A. Meyer and their combination Gincosanregistered trade mark (PHL-00701) on the brain levels of biogenic monoamines and on the serum content of prolactin, growth hormone and ACTH. Phytother. Res. 7, 139-145, 1993. 25) Collomp K. et al. Ginseng and supramaximal exercise. Sci. Sports 11, 250-251, 1996. 26) Graubaum H.J. et al. Physical performance support with combined phytotherapy. Ginseng, whitethorn and mixed pollen combination against stress. Therapiewoche 46, 1421-1445, 1996. 27) Le Gal M. et al. Pharmaton capsules in the treatment of functional fatigue: a double blind study versus placebo evaluated by a new methodology. Phytother. Res. 10, 49-53, 1996. 28) Blasius H. Phytotherapy: adaptogenic effect of ginseng. Dtsch. Apoth. Ztg. 135, 50-52, 1995. 29) Becker B.N. et al. Ginseng induced diuretic resistance. J. Am. Med. Ass. 276, 606-607, 1996. 30) Van Schepdael P. Effect of Ginseng G 115 on the physical condition of triathletes. Acta Ther. 19, 337-347, 1993. 31) Sannia A. Effetto sulla performance sportiva di durata di un'integrazione vitaminica e minerale paragonato a quello del Ginseng e dell'Eleuterococco presi isolatamente. Acta Phytotherapeutica 1, 6-12, 1998. 32) Engels H.J. et al. No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exercise. J. Am. Diet Assoc. 97, 1110-1115, 1997. 33) Morris A.C. et al. No ergogenic effect of ginseng ingestion. Int. J. Sport Nutr. 6, 263-271, 1996. 34) Han K.H. et al. Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am. J. Chin. Med. 26, 199-209, 1998. 34B) Allen J.D. et al. Ginseng supplementation does not enhance healthy young adults' peak aerobic exercise performance. J. Am. Coll. Nutr. 17, 462-466, 1998. 35) Ferrando A. et al. Effects of a standardized Panax ginseng extract on the skeletal muscle of the rat: a comparative study in animals at rest and under exercise. Planta Med. 65, 239-244, 1999. 36) Vogler B.K. et al. The efficacy of ginseng. A systematic review of randomised clinical trials. Eur. J. Clin. Pharmacol. 55, 567-575, 1999. 37) Bucci L.R. Selected herbals and human exercise performance. Am. J. Clin. Nutr. 72, 624S-636S, 2000. 38) Vaes L.P. Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence. Ann. Pharmacother. 34, 1478-1482, 2000. 39) Liebermann H.R. The effects of ginseng, ephedrine, and caffeine on cognitive performance, mood and energy. Nutr. Rev. 59, 91-102, 2001. 40) Engels H.J. et al. Effects of ginseng supplementation on supramaximal exercise performance and short-term recovery. J. Strength Cond. Res. 15, 290-295, 2001. 41) Cardinal B.J. et al. Ginseng does not enhance psychological well-being in healthy, young adults: results of a double-blind, placebo-controlled, randomized clinical trial. Journal Of The American Dietetic Association 101, pp. 655-660, 2001. 42) Cabral de Oliveira A.C. et al. Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 130, 369-377, 2001. 5/7 Ginseng 43) Kennedy D.O. et al. Dose dependent changes in cognitive performance and mood following acute administration of Ginseng to healthy young volunteers. Nutr. Neurosci. 4, 295-310, 2001. 44) Murphy L.L. et al. Ginseng, sex behavior, and nitric oxide. Ann. N. Y. Acad. Sci. 962, 372-377, 2002. 45) Kennedy D.O. et al. Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults. Physiol. Behav. 75, 739-751, 2002. 46) Coon J.T. et al. Panax ginseng: A Systematic Review of Adverse Effects and Drug Interactions. Drug Saf. 25, 323-344, 2002. 47) Caron M.F. et al. Electrocardiographic and hemodynamic effects of panax ginseng. Ann. Pharmacother. 36, 758-763, 2002. 48) Hong B. et al. A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 168(5):2070-3, 2002. 49) Kim D.H. et al. Effects of ginseng saponin administered intraperitoneally on the hypothalamo-pituitary-adrenal axis in mice. Neurosci Lett. 343(1):62-6, 2003. 50) Chan L.Y. et al. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod. 18(10):2166-8, 2003. 51) Kiefer D. Et al. Panax ginseng. Am Fam Physician. 68(8):1539-42, 2003. 52) Kim S. et al. Ginsenosides inhibit NMDA receptor-mediated epileptic discharges in cultured hippocampal neurons. Arch Pharm Res. 27(5):524-30, 2004. 53) Shen L.H. et al. Ginsenoside Rg1 promotes proliferation of hippocampal progenitor cells. Neurol Res. 26(4):422-8, 2004. 54) Harttz A.J. et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med. 34(1):51-61, 2004. 55) Kennedy D.O. et al. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacol Biochem Behav. 79(3):401-11, 2004. 56) Voces J. et al. Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats. Braz J Med Biol Res. 37(12):1863-71, 2004. 57) Cabral de Oliveira A.C. et al. Protection of Panax ginseng in injured muscles after eccentric exercise. J Ethnopharmacol. 97(2):211-4, 2005. 58) Reay J.L. et al. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol. 19(4):357-65, 2005. 59) Reay J.L. et al. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J Psychopharmacol. 2006 Jan 9; [Epub ahead of print]. 60) Hwang S.Y. et al. Panax ginseng improves survival and sperm quality in guinea pigs exposed to 2,3,7,8-tetrachlorodibenzo- p-dioxin. BJU Int. 94(4):663-8, 2004. 61) Chen F. et al. Reductions in levels of the Alzheimer's amyloid beta peptide after oral administration of ginsenosides. FASEB J. 20(8):1269-71, 2006. 62) Wang Z.J. et al. Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms. Chem Biol Interact. 2006 Jan 5;159(1):58-64, 2006. 63) Elam J.L. et al. Methodological issues in the investigation of ginseng as an intervention for fatigue. Clin Nurse Spec. 20(4):183-9, 2006. 64) Kim J.H. et al. Neuroprotective effects of ginsenoside Rg3 against homocysteine-induced 6/7 Ginseng excitotoxicity in rat hippocampus. Brain Res. 1136(1):190-9, 2007. 65) Etheridge A.S. et al. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med. 73(8):731-41, 2007. 66) Zhang G. et al. Panax ginseng ginsenoside-Rg(2) protects memory impairment via anti-apoptosis in a rat model with vascular dementia. J Ethnopharmacol. 115(3):441-8, 2008. 67) Hielm-Bjorkman A. et al. Panax Ginseng in combination with brewers' yeast (Gerivet) as a stimulant for geriatric dogs: a controlled-randomized blinded study. J Vet Pharmacol Ther. 30(4):295-304, 2007. 68) Zhang G. et al. Panax ginseng ginsenoside-Rg(2) protects memory impairment via anti-apoptosis in a rat model with vascular dementia. J Ethnopharmacol. 115(3):441-8, 2008. 69) Zhang G. et al. Panax ginseng ginsenoside-Rg(2) protects memory impairment via anti-apoptosis in a rat model with vascular dementia. J Ethnopharmacol. 115(3):441-8, 2008. 70) Lee S.T. et al. Panax Ginseng Enhances Cognitive Performance in Alzheimer Disease. Alzheimer Dis Assoc Disord. 2008 Jun 17. [Epub ahead of print]. 71) Yang L. et al. Ginsenoside Rg3 promotes beta-amyloid peptide degradation by enhancing gene expression of neprilysin. J Pharm Pharmacol. 61(3):375-80, 2009. 72) Kim P.O. et al. Panax ginseng protects against global ischemia injury in rat hippocampus. J Med Food. 12(1):71-6, 2009 7/7
Documenti analoghi
GINSENG-RIMEDIO PER TUTTI I MALI
Con il giusto apporto di principio attivo si ritiene che venga stimolato il sistema
endocrino pituitario e surrenalico nel rilascio di ormoni stimolanti, capaci di
ritardare l’insorgere della fatic...
Ginseng - Piante medicinali
“The effects of various ginsenosides on calmodulin-dependent phosphodiesterase isozymes have been investigated.
Ginsenosides were found to be potent inhibitors of bovine heart calmodulin-dependent ...