danarti N 15

gamoyenebis instruqcia
kenalogi 40 saineqcio suspenzia
(Kenalog 40)
triamcinoloni
savaWro dasaxeleba
kenalogi 40 (Kenalog 40)
zogadi daxasiaTeba
saerTaSoriso arapatenturi dasaxeleba
triamcinoloni (Triamcinolone).
aRwera
TeTri suspenzia, praqtikulad nawilakebis da aglomeratebis gareSe, susti
benzilis spirits suniT.
Semadgenloba
suspenziis 1 ml Seicavs 40 mg triamcinolonis acetonids.
damxmare nivTierebebi: natriumis karmeloza, natriumis qloridi, benzilis
spiriti, polisorbat 80, saineqcio wyali.
gamoSvebis forma
saineqcio suspenzia
samkurnalo saSualebis klasifikaciis kodi
glukokortikoidebi, kortikoidebi sistemuri gamoyenebisaTvis.
aTq kodi: H02AB08
farmakologiuri Tvisebebi
farmakodinamika
triamcinolonis ZiriTadi efeqti dakavSirebulia mis glukokortikoidul
moqmedebasTan da anTebiTi reaqciis daTrgunvasTan. kortikosteroidebi Tavidan
acileben an Trgunaven anTebiTi procesis sawyis niSnebs (siwiTle, gamkvriveba,
lokaluri hiperTermia, SeSupeba), aseve mis Sedegebs. fibroblastebis
proliferaciis da kolagenis garTulebebis CaTvliT.
farmakokinetika
koncentraciis (AUC) mrudis qveS farTobebis Sedareba saxsarSida da
intramuskularulad Seyvanisas, imaze miuTiTebs, rom orive formisas aRiniSneba
sruli absorbcia.
prednizolonis msgavsad, triamcinoloni ZiriTadad RviZlSi metabolizdeba.
preparatis 15%-ze naklebi eqskretirdeba SardiT Seucvleli saxiT.
identificirebulia triamcinolonis sami metaboliti; metaboluri profili
preparatis Seyvanis samive gzis semTxvevaSi msgavsia. triamcinolonis acetonidis
metabolitebs miekuTvneba 6-beta-hidroqsitriamcinolon acetonidi, 21-karboqsi-6beta- hidroqsitriamcinolon acetonidi da 21- karboqsitriamcinolon acetonidi.
klinikurma kvlevebma kortikosteroidebis adgilobrivi gamoyenebisas ar
gamoavlina mniSvnelovani sistemuri absorbcia, ris Sedegadac dedis rZeSi misi
raodenoba gansazRradia. sistemurad daniSnuli kortikosteroidebi dedis rZeSi
sekretirdeba im raodenobiT, rom axalSobilebSi gverdiTi movlenebis
ganviTareba naklebsavaraudoa.
miRebis Cvenebebi
kenalogi 40 – triamcinolonis acetonidis wyliani suspenzia, prolongirebuli
moqmedebis, sistemuri da adgilobrivi gamoyenebisaTvis. is sinTezuri
kortikosteroidia, romelic axdens anTebissawinaaRmdego, imunosupresiul,
qavilis sawinaaRmdego da antialergiul moqmedebas. preparati ar iwvevs
arteriul hipertenzias. hipofizze misi damTrgunveli moqmedeba ramdenadme
sustia imave dozebiT sxva kortikosteroidebTan SedarebiT.
triamcinoloni acetonidi rekomendebulia Semdegi daavadebebis samkurnalod:
• alergiuli mdgomareobebi sezonuri da srulwliani alergiuli rinitis,
asTmis, atopiuri da kontaqturi dermatitis,medikamenturi reaqciebis,
Sratismeri daavadebis da xorxis mwvave arainfeqciuri SeSupebis CaTvliT.
anafilaqsiuri reaqciebisas kortikosteroidebi ar iniSneba mwvave fazis
samkurnalod, Tumca isini gamoiyeneba mogvianebiTi stadiis Tavidan
asacileblad.
• revmatoiduli daavadebebi
kortikosteroidebi ZiriTadad gamoiyeneba pacientebSi, mZime revmatoiduli
arTritiT, sadac mosalodnelia neladmoqmedi antirevmatiuli preparatebis
dadebiTi efeqti. isini naCvenebia mwvave podagris, mwvave araspecifiuri
maankilozebeli spondiloarTritis, bursitis, epikondilitis,
posttravmuli osteoarTritis, osteoarTritisas fsoriazuli arTritis da
sinovitis xanmokle TerapiisaTvis.
• dermatologiuri daavadebebi
kortikosteroidebi rekomendebulia bulozuri herpetimorfuli
dermatitisas, eqsfoliaciuri dermatitis, mZime multiformuli eriTemis,
mZime fsoriazis, mZime seboreuli dermatitis, egzemis, atopiuri dermatitis,
diskoiduri mgluras, kontaqturi dermatitis, budovani aloceciisas,
pemfigusis da sxvadasxva mwvave da qronikuli dermatozebisas.
• ofTalmologiuri daavadebebi
kortikosteroidebi rekomendebulia mZime mwvave da qronikuli alergiuli
da anTebiTi mdgomareobebisas, alergiuli koniunqtivitis, rqovanas kideebis
alergiuli wylulebis, Tvalis wina kameris anTebis, qorioretinitis,
difuzuri ukana uveitis da qoreitis CaTvliT, Tvalis herpesuli dazianeba,
iriti da iridocikliti, keratiti, Tvalis nervis nevriti da simpaTikuri
ofTalmia.
• endokrinuli daavadebebi
kortikosteroidebi rekomendebulia Tirkmelzeda jirkvlis pirveladi da
meoreuli ukmarisobis, kongenitaluri hiperplaziis, simsivnur
daavadebasTan dakavSirebuli hiperkalcemiis, araCirqovani Tireoiditis da
adisonis daavadebis samkurnalod.
• kuW-nawlavis traqtis daavadebebi
kortikosteroidebi naCvenebia regionuli enteritis gamwvavebis (kronis
daavadeba) da wylulovani kolitis samkurnalod.
• respiratoruli daavadebebi
kortikosteroidebi gamoiyeneba aspiraciuli pnevmoniis, beriliozis,
lefleris sindromis, sarkoidozis da diseminirebuli tuberkulozis
samkurnalod.
• sxva daavadebebi
tuberkulozuri meningiti, gafantuli sklerozi (kortikosteroidebi
gamoiyeneba gafantuli sklerozis gamwvavebis samkurnalod, isini amcireben
daavadebis gamwvavebis xangrZlivobas, magram ar axdenen gavlenas mis
progresirebaze).
miRebis wesi da dozebi
triamcinolonis dozirebis sqema variabiluria da SerCeuli unda iqnas
individualurad, daavadebisgan da Catarebul mkurnalobaze pacientis pasuxidan
gamomdinare. saWiroa kortikosteroidebis minimaluri dozebis daniSvna,
mkurnalobis erTdouli kontroliT. dozis Semcirebis aucileblobisas, saWiroa
misi TandaTan Semcireba.
doza unda ganisazRvros saxsris zomis, daavadebis mdgomareobis da pacientis
pasuxis Sesabamisad.
Terapiuli efeqti, rogorc wesi vlindeba 2-3 kviris Semdeg. Tumca sasurveli
dadebiTi efeqtis gamosavlenad SesaZlebelia saWiro iyos 6 kviraze meti.
kenalogi 40 ar unda dainiSnos intravenurad!
intramuskularuli Seyvana
kenalogi 40 iniSneba intramuskularulad doziT 40 – 80 mg.rekomendebuli sawyisi
doza mozrdilebisa da 12 welze meti asakis bavSvebisaTvis: 40 mg.
aucileblobisas erTjeradi doza SeiZleba gaizardos 100-120 mg.
6 – 12 wlis bavSvebisaTvis rekomendebuli sawyisi doza: 0,03-0,2 mg/kg
intramuskolarulad intervaliT 1-dan 7 dRemde.
kenalogi 40 intramuskularuli Seyvnam xSirad SeiZleba Secvalos sawyisi
peroraluri Terapiia.
erTi parenteraluri doza sakmarisia daavadebis kontrolisaTvis 4-7 dRidan 3-4
kviramde. erTjeradi 40-60 mg dozis gamoyenebam SeiZleba gamoiwvios simptomebis
remisia mTeli sezonis ganmavlobaSi Tivis cxelebis, an mcenareTa mtvriT
gamowveuli asTmis dros.
Seyvanis aRniSnuli gza iwvevs dadebiT Sedegs mag. asTmis dros, magram SeiZleba
dakavSirebuli iyos kortikosteroidebis regularuli gamoyenebisas SesaZlo
gverdiTi movlenebis gamovlenasTan.
saxsarSida Seyvana
amJamad triamcinoloni iSviaTad gamoiyeneba revmatoiduli arTritis sistemuri
TerapiisaTvis; is seiZleba Seyvanil iqnas saxsarSi tkivilis da anTebis
Sesamsubuqeblad revmatoiduli, podagruli, fsoriazuliarTritis da
osteoarTritisas. pacientebi gafrTxilebulni unda iyvnen imis Sesaxeb, rom
simptomebis gaumjobesebisas ar gadatvirTon saxsari. saxsarSida ineqciebi,
romlebic meordeba xangrZlivi drois ganmavlobaSi, SesaZlebelia gaxdes saxsris
mZime destruqciis da Zvlis nekrozis mizezi.
triamcinolonis acetonidis Cveulebrivi doza saxsarSida SeyvanisaTvis
mozrdilebSi: 5 – 10 mg mcire saxsrebisaTvis da 20 – 60 mg msxvili
saxsrebisaTvis. ramodenime saxsarSi Sesayvani sumaruli doza ar unda
aRematebodes 80 mg-s.
rekomendebuli sawyisi doza 12 – 18 wlis bavSvebisaTvis: 2,5 – 40 mg. Semdegi
dozebi SeiZleba gaizardos pacientis pasuxis gaTvaliswinebiT.
triamcinoloni SeiZleba Seyvanil iqnas adgilobrivad bursitis, an
tendosinovitis Sesamsubuqeblad. preparatis myesebs Soris da myesis CanTaSi
Seyvanisas, aucilebelia sifrTxilis dacva; preparatis uSualod myesebSi Seyvanam
SeiZleba gamoiwvios misi gagleja. doza damokidebulia sinovialur sivrceze da
anTebis xarisxze.
dazianebis adgilze Seyvana
Cveulebric, SeyavT 5 – 10 mg triamcinolinis acetonidi, gayofili dazianebuli
ubnis farTobis Sesabamis dozebad.
rekomendebuli sawyisi doza 12 – 18 wlis bavSvebSi: 2,5 – 40 mg. Semdgomi dozebi
SeiZleba gaizardos pacientis pasuxidan gamomdinare.
didi farTobebisas ineqciis ubanze akeTeben ramodenime mcire ineqcias.rogorc
wesi, sakmarisia 2-3 ineqcia yovel 2-3 kviraSi.
Seyvanis aRniSnuli meTodi gamoiyeneba didi farTobis dazianebuli ubnebis
arsebobisas, hag. fsoriazis, an kerovani alopeciisas.
bavSvebi
triamcinolonis acetonidis intramuskularuli gamoyeneba 6 wlamd bavSvebSi da
saxsarSida gamoyeneba 12 wlamde bavSvebSi mkacri Cvenebebis gareSe rekomendebuli
ar aris. mkurnalobis periodSi aucilebelia aseTi pacientebis zrdis da
ganviTarebis kontroli.
Tirkmlis funqciis darRvevisas dozis koreqcia saWiro ar aris.
RviZlis funqciis mZime darRvevisas mkurnalobis dawyeba saWiroa naxevari doziT,
radgan kortikosteroidebis efeqti SeiZleba potencirebuli iyos pacientTa am
kategoriisaTvis.
triamcinolonis acetonidi SeiZleba ganzavdes, an Seerios adgilibriv
saanesTezio saSualebebs. kortikosteroiduli preparatebi dazianebis ubanSi
Seyvanisas SeiZleba gazavdes saineqcio wyalSi (steriluri), an 0,9% natriumis
qloridis xsnarSi. gazavebuli suspenzia gamosayeneblad vargisia 7 dRis
ganmavlobaSi.
gverdiTi movlenebi
rogorc wesi, gverdiTi movlenebi SeiZleba Tavidan iqnas acilebuli preparatis
moxsniT. savaraudo gverdiTi efeqtebis ganviTarebis sixSire hipoTalamohipofizur-Tirkmelzeda jirkvlis sistemis daTrgunvis CaTvliT, damokidebulia
samkurnalo saSualebis dozirebaze, misi miRebis wessa da mkurnalobis
xangrZlivobaze. miuxedavad imisa, rom triamcinolonis absorbcia saxsarSida
Seyvanis Semdeg iSviaTad aRiniSneba, pacientebi unda imyofebodnen samedicino
dakvirvebis qveS SesaZlo gverdiTi movlenebis kontrolisaTvis.
anTebissawinaaRmdego da imunosupresiuli moqmedeba: infeqciebis mimReblobis da
simZimis xarisxis momateba klinikuri simptomebis supresiiT da gamovlinebebiT,
oportunistuli infeqciebi, tuberkulozis recidivi.
wyal-eleqtrolituri balansi: organizmSi natriumis da siTxis Sekaveba, gulis
SegugebiTi ukmarisoba winaswari ganwyobis mqone pacientebSi, hipokaliemiis
Sedegad ariTmiebi an cvlilebebi ekg-ze, organizmidan kalciumis gamoyofis
gaZliereba, hipertenzia.
sayrden-mamoZravebeli aparatis mxriv:
kunTebis sisuste, daRliloba”steroiduli” miopaTia, kunTovani masis daqveiTeba
(atrofia), osteoporozi, xerxemlis kompresiuli motexiloba, motexilobisas
Zvlebis Sexorcebis Seneleba, TeZos an mxris Zvlis Tavis aseptiuri nekrozi,
lulovani Zvlebis paTologiuri (spontanuri) motexilobebi, myesebis gagleja.
hipermgrZnobelobis reaqciebi: anafilaqtoiduri reaqciebi, anafilaqsiuri reaqcia
anafilaqsiuri Sokis CaTvliT, angionevrozuli SeSupeba, gamonayari, qavili da
WinWris cieba, gansakuTrebiT anamnezSi medikamenturi alergiis arsebobisas.
kanis safaris mxriv: Wrilobis Sexorcebis Seneleba, kanis ganleva, peteqiebi,
eqximozebi, momatebuli oflianoba, purpura, striebi, hirsutizmi, ferimWamelebi,
wiTeli mgluras msgavsi dazianeba, kanis sinjebis Catarebisas reaqciis
daTrgunva.
kuW-nawlavis traqtis mxriv: dispepsia, kuWis da Tormetgoja nawlavis wyluli,
pankreatiti, muclis Seberiloba, wylulovani ezofagiti, kandidozi.
nervuli sistemis mxriv: eiforia, fsiqikuri damokidebulebis sindromi, depresia,
uZiloba, krunCxvebi, qalaSida wnevis momateba mxedvelobis nervis SeSupebiT
(naTxemis fsevdosimsivne), vertigo, Tavis tkivili, nevriti an paresTezia, adre
arsebuli fsiqikuri darRvevebis da epilefsiis simptomebis gamwvaveba. aris
cnobebi fsiqikuri reaqciebis Sesaxeb: afeqturi darRvevebi (gaRizianebadoba,
eiforia, depresia, labiluroba, suiciduri azrebi), fsiqozuri reaqciebi (maniebi,
halucinaciebi, Sizofreniis simptomebis gamwvaveba), qcevis darRveva, SfoTva,
Zilis darRveva, kognitiuri disfunqcia, cnobierebis darRvevis da amneziis
CaTvliT. CamoTvlili movlenebi SeiZleba aRiniSnos rogorc mozrdilebSi, aseve
bavSvebSi. mozrdil pacientebSi seriozuli arasasurveli reaqciebis sixSire
Seadgens 5-6 %-s.
endokrinuli sistemis mxriv: menstrualuri ciklis darRveva an amenorea, kuSingis
sindromi, bavSvebsa da mozardebSi zrdis Seferxeba, stresisas (travmebi,
operaciebi, daavadeba) Tirkmelzeda jirkvlis da hipofizis meoradi ukmarisoba,
naxSirwylebisadmi tolerantobis daqveiTeba, latenturi Saqriani diabetis
manifestacia, diabetisas insulinis an peroraluri hipoglikemiuri saSualebebis
moTxovnilebis gazrda, sxeulis masis momateba, hipokalciemia, hipoproteinemia,
madis momateba.
grZnobaTa organoebis da mxedvelobis mxriv: ukana subkafsularuli kataraqta,
Tvalis Sida wnevis momateba, glaukoma, egzofTalmi, mxedvelobis nervis diskis
SeSupeba, rqovanas an skleris ganleva, Tvalis meoradi virusuli an sokovani
infeqciebis ganviTarebisadmi midrekileba.
sxva: manekrozebeli vaskuliti, Tromboflebiti, Tromboembolia, leikocitozi,
uZiloba, gulis wasvla.
preparatis moxsnis Semdgomi simptomebi da gamovlinebebi: cxeleba, mialgia,
arTralgia, riniti, koniunqtiviti, kanze mtkivneuli qavana kvanZebi, wonis
dakargva. preparatis xangrZlivi gamoyenebis Semdeg dozis Zalian mkveTrma
Semcirebam SeiZleba gamoiwvios Tirkmelzeda jirkvlis mwvave ukmarisoba,
hipotonia da sikvdili.
saxsarSida Seyvana
saxsarSida Seyvanis Semdeg gverdiTi movlenebi iSviaTad gvxvdeba. erTeul
SemTxvevebSi aRiniSna gardamavali hyperemia da Tavbrusxveva. SesaZlebelia
lokaluri simptomebis gamovleba: ineqciis Semdeg anTebiTi hyperemia, gardamavali
tkivili, gaRizianebadoba, steriluri abscesi, hiper an hipopigmentacia, Sarkos
atrofia, saxsrebSi diskomfortis SegrZneba. SesaZlebelia cximovani qsovilis
droebiTi lokaluri atrofia (Tu ineqcia gakeTda arasaxsarSida napralSi),
romelic gaivlis ramodenime kviraSi, an TveSi.
intramuskularuli ineqcia
intramuskularuli Seyvanis Semdeg, cnobilia Zlieri tkivilis gamovlenis
SemTxvevebi; aRiniSna steriluri abscesebi, kanis da kanqveSa qsovilis atrofia,
hiperpigmentacia, hipopigmentacia, Sarkos arTropaTia.
winaaRmdegCvenebebi
hipermgrZnobeloba triamcinolonis, an preparatis nebismieri sxva komponentis
mimarT.
sistemuri sokovani infeqciebisas, kortikosteroidebi winaaRmdegnaCvenebia.
kortikosteroidebi intramuskularuli gamoyenebisaTvis winaaRmdegnaCvenebia
idiopaTiuri Trombocitopeniuri purpurisas.
qvemoT CamoTvlili winaaRmdegCvenebebi SefardebiTia, damokidebulia
mkurnalobis dagegmil xangrZlivobaze da Seyvanis gzebze – sistemuri Tu
adgilobrivi – da umTavresad gamafrTxilebeli an prevenciuli xasiaTi aqvs
aqtiuri anTeba
kortikosteroidebma SeiZleba daaqveiTon organizmis pasuxi infeqciebze da
gaaaqtiuron, an gamoiwvion adgilobrivi an sistemuri infeqciebis, sistemuri
sokovani daavadebebis gamwvaveba, gaaaqtiuros antibiotikebiT arakontrolirebadi
infeqciebi, aseve gaaaqtiuros latenturi tuberkulozi an gaaRrmavos
tuberkulozis klinikuri gamovlineba.
diabeti
kortikosteroidebiT mkurnalobisas, SesaZloa garTuldes kontroli daavadebis
mimdinareobaze.
osteoporozi
kortikosteroidebiT xangrZlivi Terapiisas, osteoporozis movlenebi SeiZleba
gaZlierdes, gansakuTrebiT xandazmul pacientebSi xerxemlis kompresiuli
dazianebis saSiSroebis ganviTarebamdec ki.
miopaTia
anamnezSi kortikosteroidebiT inducirebuli proqsimaluri miopaTiis arseboba
warmoadgens winaaRmdegCvenebas am gverdiTi movlenis ganviTarebis
gansakuTrebuli riskis gamo. kortikosteroidebis moxsnis Semdeg, miopaTia
Cveulebriv qreba ramdenime Tvis ganmavlobaSi. am gverdiTi efeqtis ganviTarebis
riski umTavresad bavSvebSia.
peptiuri wyluli
peptiuri wylulis ganviTareba garkveulwilad SeiZleba dakavSirebuli iyos
kortikosteroidebis gamoyenebasTan. amasTan arsebobs perforaciis, an sisxldenis
ganviTarebis riski. pacientebs, romlebic damatebiT iReben arasteroidul
anTebissawinaaRmdego preparatebs, aqvT maRali riski.
fsiqozi
anamnezSi paranoiis, an dapresiis mqone pacientebSi, mocemuli preparatis miRebam
SeiZleba gazardos suicidis riski.
qsovilovani reparacia
qsovilovani reparaciis Seneleba SeiZleba mniSvnelovani iyos axali nawlavuri
anasTomozebis mqone pacientebSi.
vaqcinacia
pacientebi, romlebic iReben kortikosteroidebs, ar unda aicran ybayuraze.
nebismieri sxva vaqcinacia ar unda CautardeT pacientebs, romlebic iReben
kortikosteroidebis maRal dozebs, radgan SesaZlebelia nevrologiuri
garTulebebi, an antisxeulebis arasakmarisi gamomuSaveba.
triamcinolonis acetonidis daniSvna intramuskularuli ineqciebis saxiT 6
wlamde bavSvebSi, an saxsarSida ineqciis saxiT, an dazianebis ubanze ineqciis
saxiT12 wlamde asakis bavSvebSi mkacri Cvenebebis gareSe ar aris rekomendebuli.
kortikosteroidebis adgilobrivi gamoyeneba (SedarebiT) winaaRmdegnaCvenebia:
• iseTi dazianebebisas, rogoricaa impetigo, kanis triqopitia da martivi
herpesi;
• axalSobilebSi;
• Cveulebrivi ferimWamelebisas;
• rozaceisas;
• trofikuli wylulebisas.
dozis gadaWarbeba
aris erTeuli monacemebi dozis mwvave gadaWarbebis an sikvdilis Sesaxeb.
simptomebi. dozis gadaWarbeba Cveulebriv mxolod ramodenime kviris
ganmavlobaSi Zalian maRali dozebis miRebis Semdeg SeiZleba gaxdes gverdiTi
movlenebis ganviTarebis mizezi (umTavresad kuSingis sindromi).
mkurnaloba: SemanarCunebeli da simptomaturia. specifiuri antidoti ar aris.
hemodializi ar iwvevs organizmidan triamcinolonis gamoyofis mnisvnelovan
daCqarebas.
usafrTxoebis zomebi
kenalogi 40-is intranazaluri, subkoniunqtivaluri, myesSida, retrobulbaruli
da intraokularuli (intravitrealuri) ineqciebis gamoyenebis sakmarisi kvlevebi
ar Catarebula. preparatis intravitrealuri Seyvanisas, aris monacemebi
endoftalmitis, momatebuli TvalisSida wnevis damxedvelobis darRvevis Sesaxeb,
mxedvelobis dakargvis CaTvliT. cnobilia sibrmavis ganviTarebis SemTxvevebi
kortikosteroidis suspenziis cxviris niJarebSi da Tavis areSi dazianebul
qsovilebSi Seyvanis Semdeg. iyo cnobebi anafilaqsiuri reaqciebis da
anafilaqsiuri Sokis Sesaxeb (letaluri gamosavliTac ki) pacientebSi, romlebic
iRebdnen triamcinolonis acetonidis ineqciebs Seyvanis gzis miuxedavad.
orsuloba da laqtacia
miuxedavad imisa, rom teratogenuli efeqti ar iqna dadgenili, orsulobis dros
saWiroa triamcinolonis acetonidis daniSvnisagan Tavis Sekaveba. adamianebSi
reproduqciul funqciaze triamcinolonis gavlenis arasakmarisi monacemebis
gamo, maTi gamoyeneba orsulobis da laqtaciis periodSi naCvenebia mxolod im
SemTxvevaSi, rodesac mosalodneli sargebeli aRemateba dedisa da nayofisTvis
potenciur risks. axalSobilebi, romelTa dedebi orsulobis periodSi iRebdnen
kortikosteroidebis mniSvnelovan dozebs, gulmodgined unda iqnen gamokvleulni
SesaZlo hipoadrenalizmis simptomebis gamosavlenad. am dros neonataluri
Tirkmelzeda jirkvlis ukmarisoba iSviaTad aRiniSneba.
gavlena avtotransportis da sxva meqanizmebis marTvis unarze
kenalogi 40 ar axdens gavlenas avtotransportis da sxva meqanizmebis marTvis
unarze.
urTierTqmedeba sxva samkurnalo saSualebebTan
amfotericini da arakaliumSemnaxveli preparatebis ineqciebi: SesaZlo
hipokaliemiis ganviTarebis gamo, pacientebi unda imyofebodnen samedicino
meTvalyureobis qveS.
antiqolinesTerazuli saSualebebi: SeiZleba daqveiTdes aRniSnuli preparatebis
efeqti (antagonizirebuli).
peroraluri antikoagulantebi: kortikosteroidebma SeiZleba moaxdinon
antikoagulanturi moqmedebis potencireba, an daaqveiTon maTi moqmedeba.
pacientebi, romlebic erTdroulad iReben peroralur antikoagulantebs da
kortikosteroidebs, unda imyofebodnen samedicino dakvirvebis qveS.
antidiabeturi saSualebebi: kortikosteroidebma SeiZleba gazardon glukozis
done sisxlSi; aucilebelia glikemiis kontroli, gansakuTrebiT Terapiis
dasawyisSi, preparatis miRebis sewyvetisas da kortikosteroidis dozis
Secvlisas.
antihipertenziuli saSualebebi diuretikebis CaTvliT: kortikosteroidebi
aqveiTeben antihipertenziuli saSualebebis da diuretikebis moqmedebas; SeiZleba
gaizardos diuretikebis hipokalemiuri efeqti (acetazolamidis CaTvliT).
tuberkulozis sawinaaRmdego preparatebi: sisxlSi SeiZleba daqveiTdes
izoniazidis koncentracia.
ciklosporini: aucilebelia ciklosporinis momatebuli toqsiurobis
monitoringis Catareba.
saTiTuras glikozidebi: saTiTuras toqsiuroba SesaZloa gaizardos.
estrogenebi peroraluri kontraceptivebis CaTvliT: SeiZleba gaizardos
kortikosteroidebis naxevargamoyofis periodi da koncentracia, maSin, rodesac
klirensi qveiTdeba.
RviZlis fermentebis induqtorebi (mag. barbituratebi, fenitoini, karbamazepini,
rifampicini, primidoni, aminoglutetimidi): SesaZlebelia kenalogi 40 metaboluri
klirensis momateba.pacientebi unda imyofebodnen samedicino dakvirvebis qveS
steroidebis efeqtis SesaZlo daqveiTebis gamo, am dros saWiroa dozis Sesabamisi
koreqcia.
adamianis zrdis hormoni: SesaZlebelia zrdis stimulirebis efeqtis gaZliereba.
ketokonazoli: SesaZlebelia kortikosteroidebis klirensis daqveiTeba efeqtis
Semdgomi gaZlierebiT.
aramadepolarizebeli kunTovani relaqsantebi: kortikosteroidebma SeiZleba
gaaZlieron, an Seasuston nerv-kunTovani gadacemis blokada.
arasteroiduli anTebissawinaaRmdego saSualebebi (aass): kortikosteroidebma
SeiZleba gazardon aass-s miRebasTan dakavSirebuli kuW-nawlavuri sisxldenis da
wylulis ganviTarebis riski da/an simZimis xarisxi.
kortikosteroidebma SeiZleba daaqveiTon sisxlis SratSi salicilatebis done,
riTac auareseben maT efeqturobas. piriqiT kortikosteroidebis miRebis Sewyvetam
salicilatebis maRali dozebiT Terapiisas, SeiZleba gamoiwvios ukanasknelis
toqsiuri efeqtis gamovlena.
hipoproTrombinemiis mqone pacietebma kortikosteroidebTan erTad, sifrTxiliT
unda miiRon aspirini.
Tireoiduli preparatebi: adrenokortikosteroidebis metaboluri klirensi
qveiTdeba hipoTireozis mqone pacientebSi da izrdeba hiperTireozis mqone
pacientebSi.pacientSi Tireoiduli statusis Secvlam SeiZleba gamoiwvios
adrenokortikosteroidebis dozis koreqciis aucilebloba.
vaqcinebi: pacientebis vaqcinaciisas, romlebic iReben kortikosteroidebs,
SeiZleba aRiniSnos nevrologiuri garTulebebi da imunuri pasuxis ararseboba.
akrZalulia ampulis SigTavsis sxva preparatebTan Sereva.
Senaxvis pirobebi da vada
SeinaxeT aranakleb 250C temperaturis pirobebSi. ar gayinoT. SeinaxeT vertikalur
mdgomareobaSi.
SeinaxeT bavSvebisTvis miuwvdomel adgilas.
vargisianobis vada 3 weli.
ar gamoiyenoT SefuTvaze miTiTebuli vadis Semdeg.
afTiaqidan gacemis pirobebi
farmacevtuli produqtis jgufi II (gamoiyeneba eqimis daniSnulebiT)
SefuTva
1 ml 5 ampula blisterze muyaos kolofSi danarT furcelTan erTad.
mwarmoebeli
krka, d.d., novomesto, SmareSka cesta, 6,
8501 novomesto, slovenia.
damatebiTi informacia
respublika belorusSi warmomadgenlobis misamarTi ss “krka, d.d., novo mesto”
(slovenia): 220012, q. minski, surganovis q. 29, ofisi 28. tel: (017) 290 05 11.