Pubblicazioni - Filippo Drago
Transcript
Pubblicazioni - Filippo Drago
1 FILIPPO DRAGO PUBBLICAZIONI (peer-reviewed journals) 382. Inverse agonists - What do they mean for psychiatry? Nutt D, Stahl S, Blier P, Drago F, Zohar J, Wilson S. Eur Neuropsychopharmacol. 2016 Dec 7. 381. Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon? Androvicova R, Horacek J, Stark T, Drago F, Micale V. Pharmacol Res. 2016 Nov 21;115:200-208. 380. Silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety and increases work ability. Malaguarnera G, Bertino G, Chisari G, Motta M, Vecchio M, Vacante M, Caraci F, Greco C, Drago F, Nunnari G, Malaguarnera M. BMC Psychiatry. 2016 Nov 15;16(1):398. 379. A cannabinoid link between mitochondria and memory. Hebert-Chatelain E, Desprez T, Serrat R, Bellocchio L, Soria-Gomez E, BusquetsGarcia A, Pagano Zottola AC, Delamarre A, Cannich A, Vincent P, Varilh M, Robin LM, Terral G, García-Fernández MD, Colavita M, Mazier W, Drago F, Puente N, Reguero L, Elezgarai I, Dupuy JW, Cota D, Lopez-Rodriguez ML, Barreda-Gómez G, Massa F, Grandes P, Bénard G, Marsicano G. Nature. 2016 Nov 24;539(7630):555-559. 378. Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1. Caraci F, Tascedda F, Merlo S, Benatti C, Spampinato SF, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A. Front Pharmacol. 2016 Oct 25;7:389. 377. Lipoprotein(a) in patients with hepatocellular carcinoma and portal vein thrombosis. Malaguarnera G, Catania VE, Francaviglia A, Malaguarnera M, Drago F, Motta M, Latteri S. Aging Clin Exp Res. 2016 Nov 7. 376. Propranolol: Effectiveness and Failure in Infantile Cutaneous Hemangiomas. Praticò AD, Caraci F, Pavone P, Falsaperla R, Drago F, Ruggieri M. Drug Saf Case Rep. 2015 Dec;2(1):6. 375. Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells. Olivieri M, Amata E, Vinciguerra S, Fiorito J, Giurdanella G, Drago F, Caporarello N, Prezzavento O, Arena E, Salerno L, Rescifina A, Lupo G, Anfuso CD, Marrazzo A. J Med Chem. 2016 Nov 10;59(21):9960-9966. 2 374. Selective Serotonin Reuptake Inhibitors and Serotonin and Noradrenaline Reuptake Inhibitors Improve Cognitive Function in Partial Responders Depressed Patients: Results from a Prospective Observational Cohort Study. Castellano S, Ventimiglia A, Salomone S, Ventimiglia A, De Vivo S, Signorelli MS, Bellelli E, Santagati M, Cantarella RA, Fazio E, Aguglia E, Drago F, Di Nuovo S, Caraci F. CNS Neurol Disord Drug Targets. 2016;15(10):1290-1298. 373. Nanosystems based on siRNA silencing HuR expression counteract diabetic retinopathy in rat. Amadio M, Pascale A, Cupri S, Pignatello R, Osera C, D'Agata V, D'Amico AG, Leggio GM, Ruozi B, Govoni S, Drago F, Bucolo C. Pharmacol Res. 2016 Sep;111:713-20. 372. An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation. Iulita MF, Ower A, Barone C, Pentz R, Gubert P, Romano C, Cantarella RA, Elia F, Buono S, Recupero M, Romano C, Castellano S, Bosco P, Di Nuovo S, Drago F, Caraci F, Cuello AC. Alzheimers Dement. 2016 Nov;12(11):1132-1148. 371. Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus. Colavita M, Terral G, Lemercier CE, Drago F, Marsicano G, Massa F. Sci Rep. 2016 Jun 27;6:28454. 370. Current drug treatments targeting dopamine D3 receptor. Leggio GM, Bucolo C, Platania CB, Salomone S, Drago F. Pharmacol Ther. 2016 Sep;165:164-77. 369. Response to Letter to the Editor by Dr. Garattini. Navarria A, Drago V, Gozzo L, Longo L, Mansueto S, Pignataro G, Drago F. Value Health. 2016 Jun;19(4):510. 368. Differential control of dopamine ascending pathways by serotonin2B receptor antagonists: New opportunities for the treatment of schizophrenia. Devroye C, Cathala A, Haddjeri N, Rovera R, Vallée M, Drago F, Piazza PV, Spampinato U. Neuropharmacology. 2016 Oct;109:59-68. 367. Reactivity to addictive drugs in the methylazoxymethanol (MAM) model of schizophrenia in male and female rats. Ruda-Kucerova J, Babinska Z, Amchova P, Stark T, Drago F, Sulcova A, Micale V. World J Biol Psychiatry. 2016 Jun 21:1-14. 366. Linking the Price of Cancer Drug Treatments to Their Clinical Value. Gozzo L, Navarria A, Drago V, Longo L, Mansueto S, Pignataro G, Cicchetti A, Salomone S, Drago F. Clin Drug Investig. 2016 Jul;36(7):579-89. 3 365. The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß1-42 oligomers in mice. Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F. Pharmacol Res. 2016 Apr;106:10-20. 364. TGF-β1 prevents rat retinal insult induced by amyloid-β (1-42) oligomers. Fisichella V, Giurdanella G, Platania CB, Romano GL, Leggio GM, Salomone S, Drago F, Caraci F, Bucolo C. Eur J Pharmacol. 2016 Sep 15;787:72-7. 363. Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse. Oliveira da Cruz JF, Robin LM, Drago F, Marsicano G, Metna-Laurent M. NEUROSCIENCE, 2016, vol. 323, p. 35-42. 362. MicroRNA target prediction in glaucoma. Romano GL, Platania CB, Forte S, Salomone S, Drago F, Bucolo C. Prog Brain Res. 2015;220:217-40. 361. A key role for TGF-β1 in hippocampal synaptic plasticity and memory. Caraci F, Gulisano W, Guida CA, Impellizzeri AA, Drago F, Puzzo D, Palmeri A. Scientific Reports, 2015, vol. 5. 360. Aflibercept, bevacizumab and ranibizumab prevent glucose-induced damage in human retinal pericytes in vitro, through a PLA2/COX-2/VEGF-A pathway. Giurdanella G, Anfuso CD, Olivieri M, Lupo G, Caporarello N, Eandi CM, Drago F, Bucolo C, Salomone S. Biochemical Pharmacology, 2015, vol. 96, p. 278-287. 359. Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabbit. Leonardi A, Bucolo C, Drago F, Salomone S, Pignatello R. International Journal of Pharmaceutics, 2015, vol. 478, p. 180-186. 358. Central serotonin(2B) receptor blockade inhibits cocaine-induced hyperlocomotion independently of changes of subcortical dopamine outflow. Devroye C, Cathala A, Di Marco B, Caraci F, Drago F, Piazza PV, Spampinato U. Neuropharmacology, 2015, vol. 97, p. 329-337. 357. Controversies in Glaucoma: Current Medical Treatment and Drug Development Bucolo C, Platania CB, Reibaldi M, Bonfiglio V, Longo A, Salomone S, Drago F. Current Pharmaceutical Design, 2015, vol. 21, p.4673-4681. 356. Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes. Scuderi S, D'amico AG, Federico C, Saccone S, Magro G, Bucolo C, Drago F, D'Agata V. Journal of Molecular Neuroscience, 2015, vol. 56, p. 431-439. 4 355. Do the current performance-based schemes in Italy really work? "Success fee": a novel measure for cost-containment of drug expenditure. Navarria A, Drago V, Gozzo L, Longo L, Mansueto S, Pignataro G, Drago F. Value in Health, 2015, vol. 18, p. 131-136. 354. Does Mood Disorder Questionnaire identify sub-threshold bipolarity? Evidence studying worsening of quality of life. Carta MG, Norcini-Pala A, Moro MF, Balestrieri M, Caraci F, Dell'Osso L, Sciascio GD, Faravelli C, Hardoy MC, Aguglia E, Roncone R, Nardi AE, Drago F. Journal of Affective Disorders, 2015, vol. 183, p. 173-178. 353. Dopamine D3 receptor-dependent changes in alpha6 GABAA subunit expression in striatum modulate anxiety-like behaviour: Responsiveness and tolerance to diazepam. Leggio GM, Torrisi SA, Castorina A, Platania CB, Impellizzeri AA, Fidilio A, Caraci F, Bucolo C, Drago F, Salomone S. European Neuropsychopharmacology, 2015, vol. 25, p. 1427-1436. 352. Effects of Topical Fucosyl-Lactose, a Milk Oligosaccharide, on Dry Eye Model: An Example of Nutraceutical Candidate. Bucolo C, Musumeci M, Salomone S, Romano GL, Leggio GM, Gagliano C, Reibaldi M, Avitabile T, Uva MG, Musumeci S, Drago F. Frontiers in Pharmacology, 2015, vol. 6. 351. Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation. Pittalà V, Salerno L, Romeo G, Siracusa MA, Modica MN, Romano GL, Salomone S, Drago F, Bucolo C. European Journal of Pharmacology, 2015, vol. 752, p. 78-83. 350. Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications Marzagalli R, Scuderi S, Drago F, Waschek JA, Castorina A. International Journal of Endocrinology, 2015, vol. 2015:160928. 349. Endozepine-4 levels are increased in hepatic coma. Malaguarnera G, Vacante M, Drago F, Bertino G, Motta M, Giordano M, Malaguarnera M. World Journal of Gastroenterology, 2015, vol. 21, p. 9103-9110. 348. Expression pattern of parkin isoforms in lung adenocarcinomas. D'Amico AG, Maugeri G, Magro G, Salvatorelli L, Drago F, D'Agata V. Tumor Biology, 2015, vol. 36, p. 5133-5141. 347. Expression profile of parkin isoforms in human gliomas. Maugeri G, D'Amico AG, Magro G, Salvatorelli L, Barbagallo GM, Saccone S, Drago F, Cavallaro S, D'Agata V. International Journal of Oncology, 2015, vol. 47, p. 1282-1292. 346. Folate status in type 2 diabetic patients with and without retinopathy. Malaguarnera G, Gagliano C, Salomone S, Giordano M, Bucolo C, Pappalardo A, Drago F, Caraci F, Avitabile T, Motta M. Clinical Ophthalmology, vol. 9, p. 1437-1442. 5 345. Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach. Platania CB, Di Paola L, Leggio GM, Romano GL, Drago F, Salomone S, Bucolo C. Frontiers in Pharmacology, 2015, vol. 6. 344. Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity. Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S. European Journal of Pharmacology, 2015, vol. 764, p. 256-263. 343. Nrf2 activators modulate oxidative stress responses and bioenergetic profiles of human retinal epithelial cells cultured in normal or high glucose conditions. Foresti R, Bucolo C, Platania CM, Drago F, Dubois-Randé JL, Motterlini R. Pharmacological Research, 2015, vol. 99, p. 296-307. 342. PACAP Modulates Expression of Hypoxia-Inducible Factors in StreptozotocinInduced Diabetic Rat Retina. D'Amico AG, Maugeri G, Reitano R, Bucolo C, Saccone S, Drago F, D'Agata V. Journal of Molecular Neuroscience, 2015, vol. 57, p. 501-509. 341. PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures. Castorina A, Waschek JA, Marzagalli R, Cardile V, Drago F. Plos One, 2015, vol. 10(2):e0117799. 340. Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors. Navarria A, Wohleb ES, Voleti B, Ota KT, Dutheil S, Lepack AE, Dwyer JM, Fuchikami M, Becker A, Drago F, Duman RS. Neurobiology of Disease, 2015, vol. 82, p. 254-261. 339. The attributable burden of panic disorder in the impairment of quality of life in a national survey in Italy. Carta MG, Moro MF, Aguglia E, Balestrieri M, Caraci F, Dell'Osso L, Di Sciascio G, Drago F, Hardoy MC, D'Aloja E, Machado S, Roncone R, Faravelli C. International Journal of Social Psychiatry, 2015, vol. 61, p. 93-99. 337. The dopamine D3 receptor: From preclinical studies to the treatment of psychiatric disorders. Drago F. European Neuropsychopharmacology, 2014, vol. 25, p. 1399-1400. 336. Long-term efficacy of latanoprost in primary congenital glaucoma. Uva MG, Avitabile T, Reibaldi M, Bucolo C, Drago F, Quaranta L, Lionetti E, Longo A. Eye, 2014, vol. 28, p. 53-57. 335. New definition of addiction proposed by the American Society of Addiction Medicine: Which implications for the treatment of tobacco dependence? Caraci F, Drago F. 6 European Neuropsychopharmacology, 2014, vol. 24, p. 1-4. 334. Salomone S, Foresti R, Villari A, Giurdanella G, Drago F, Bucolo C Regulation of vascular tone in rabbit ophthalmic artery: Cross talk of endogenous and exogenous gas mediators. Biochemical Pharmacology, 2014, vol. 92, p. 661-668, ISSN: 0006-2952, 333. Searching for Disease-Modifying Drugs in AD: Can We Combine Neuropsychological Tools with Biological Markers? Caraci F, Castellano S, Salomone S, Drago F, Bosco P, Di Nuovo. CNS & Neurological Disorders Drug Targets, 2014, vol. 13, p. 173-186. 332. Stress and corticosterone increase the readily releasable pool of glutamate vesicles in synaptic terminals of prefrontal and frontal cortex. Treccani G, Musazzi L, Perego C, Milanese M, Nava N, Bonifacino T, Lamanna J, Malgaroli A, Drago F, Racagni G, Nyengaard JR, Wegener G, Bonanno G, Popoli M. Molecular Psychiatry, 2014, vol. 19, p. 433-443 331. Eating disorders as a public health issue: Prevalence and attributable impairment of quality of life in an Italian community sample. Carta MG, Preti A, Moro MF, Aguglia E, Balestrieri M, Caraci F, Dell'Osso L, Di Sciascio G, Drago F, Faravelli C, Hardoy MC, D'Aloja E, Cossu G, Calò S, Palumbo G, Bhugra D. Int Rev Psychiatry. 2014 Aug;26(4):486-492. 330. Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain. Scuderi S, La Cognata V, Drago F, Cavallaro S, D'Agata V. Biomed Res Int. 2014 329. Evaluation of four comorbidity indices and Charlson comorbidity index adjustment for colorectal cancer patients. Marventano S, Grosso G, Mistretta A, Bogusz-Czerniewicz M, Ferranti R, Nolfo F, Giorgianni G, Rametta S, Drago F, Basile F, Biondi A. Int J Colorectal Dis. 2014 Sep;29(9):1159-69. 328. Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene. La Cognata V, Iemmolo R, D'Agata V, Scuderi S, Drago F, Zappia M, Cavallaro S. Curr Genomics. 2014 Jun;15(3):203-16. 327. Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α 2b Plus Ribavirin: Effect on Work Performance; A Randomized Clinical Trial. Malaguarnera G, Pennisi M, Gagliano C, Vacante M, Malaguarnera M, Salomone S, Drago F, Bertino G, Caraci F, Nunnari G, Malaguarnera M. Hepat Mon. 2014 May 5;14(5) 326. Homocysteine serum levels in diabetic patients with non proliferative, proliferative and without retinopathy. 7 Malaguarnera G, Gagliano C, Giordano M, Salomone S, Vacante M, Bucolo C, Caraci F, Reibaldi M, Drago F, Avitabile T, Motta M. Biomed Res Int. 2014;2014:191497. 325. NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia. D'Amico AG, Scuderi S, Maugeri G, Cavallaro S, Drago F, D'Agata V. J Mol Neurosci. 2014 May 30. 324. The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. Navarria A, Tamburella A, Iannotti FA, Micale V, Camillieri G, Gozzo L, Verde R, Imperatore R, Leggio GM, Drago F, Di Marzo V. Pharmacol Res. 2014 Sep;87:151-9. 323. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. Grosso G, Pajak A, Marventano S, Castellano S, Galvano F, Bucolo C, Drago F, Caraci F. PLoS One. 2014 May 7;9(5) 322. Influence of different surfactants on the technological properties and in vivo ocular tolerability of lipid nanoparticles. Leonardi A, Bucolo C, Romano GL, Platania CB, Drago F, Puglisi G, Pignatello R. Int J Pharm. 2014 Aug 15;470(1-2):133-40. 321. Omega-3 fatty acids and depression: scientific evidence and biological mechanisms. Grosso G, Galvano F, Marventano S, Malaguarnera M, Bucolo C, Drago F, Caraci F. Oxid Med Cell Longev. 2014;2014:313570. 320. Factors associated with colorectal cancer in the context of the Mediterranean diet: a case-control study. Grosso G, Biondi A, Galvano F, Mistretta A, Marventano S, Buscemi S, Drago F, Basile F. Nutr Cancer. 2014;66(4):558-65. 319. Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharideinduced ocular inflammation. Bucolo C, Marrazzo G, Platania CB, Romano GL, Drago F, Salomone S. J Pharm Pharmacol. 2014 Jul;66(7):954-60. 318. Therapeutic potential of cannabinoids in schizophrenia. Kucerova J, Tabiova K, Drago F, Micale V. Recent Pat CNS Drug Discov. 2014 Apr;9(1):13-25. 317. Leggio G.M., Camillieri G., Platania C.B., Castorina A., Marrazzo G., Torrisi S.A., Nona C.N., D'Agata V., Nobrega J., Stark H., Bucolo C., Le Foll B., Drago F., Salomone S. (2014): Dopamine D3 receptor is necessary for ethanol consumption: an approach with buspirone. Neuropsychopharmacology Jul;39(8):2017-28. 8 316. Scuderi S., D'Amico A.G., Castorina A., Federico C., Marrazzo G., Drago F., Bucolo C., D'Agata V. (2014): Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death. J Mol Neurosci. vol. 54, p. 395-404 315. Gagliano C., Caruso S., Napolitano G., Malaguarnera G., Cicinelli M.V., Amato R., Reibaldi M., Incarbone G., Bucolo C., Drago F., Avitabile T. (2014): Low levels of 17-β-oestradiol, oestrone and testosterone correlate with severe evaporative dysfunctional tear syndrome in postmenopausal women: a case-control study. Br J Ophthalmol Mar;98(3):371-6. 314. Salomone S., Piazza C., Vitale D.C., Cardì F., Gugliotta B., Drago F. (2104): Pharmacokinetics of a new subcutaneous diclofenac formulation administered to three body sites: quadriceps, gluteus, and abdomen. Int J Clin Pharmacol Ther Feb;52(2):129-34. 313. Grosso G., Mistretta A., Marventano S., Purrello A., Vitaglione P., Calabrese G., Drago F., Galvano F. (2014): Beneficial effects of the mediterranean diet on metabolic syndrome. Curr Pharm Des 20(31):5039-44. 312. Nolfo F., Rametta S., Marventano S., Grosso G., Mistretta A., Drago F., Gangi S., Basile F., Biondi A. (2013): Pharmacological and dietary prevention for colorectal cancer. BMC Surg 13 Suppl 2:S16. 311. Grosso G., Buscemi S., Galvano F., Mistretta A., Marventano S., La Vela V., Drago F., Gangi S., Basile F., Biondi A. (2014): Mediterranean diet and cancer: epidemiological evidence and mechanism of selected aspects. BMC Surg 13 Suppl 2:S14. 310. Biondi A., Grosso G., Mistretta A., Marventano S., Toscano C., Drago F., Gangi S., Basile F. (2014): Laparoscopic vs. open approach for colorectal cancer: evolution over time of minimal invasive surgery. BMC Surg 13 Suppl 2:S12. 309. Castorina A., Scuderi S., D'Amico A.G., Drago F., D'Agata V. (2014): PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways. Exp Cell Res Mar 10;322(1):108-21. 308. Carta M.G., Massidda D., Moro M.F., Aguglia E., Balestrieri M., Caraci F., Dell'Osso L., Di Sciascio G., Drago F., Faravelli C., Hardoy M.C., Calò S., Pollice R., Fortezzo A., Akiskal H. (2014): Comparing factor structure of the Mood Disorder Questionnaire (MDQ): In Italy sexual behavior is euphoric but in Asia mysterious and forbidden. J Affect Disord Feb;155:96-103. 307. D'Amico A.G., Scuderi S., Leggio G.M., Castorina A., Drago F., D'Agata V. (2013): Increased hippocampal CREB phosphorylation in dopamine D3 receptor knockout mice following passive avoidance conditioning. Neurochem Res Dec;38(12):2516-23. 306. Vitale D.C., Piazza C., Sinagra T., Urso V., Cardì F., Drago F., Salomone S. (2013): Pharmacokinetic characterization of tizanidine nasal spray, a novel intranasal delivery method for the treatment of skeletal muscle spasm. Clinical Drug Investigation Oct 2. 9 305. Bosco P., Ferri R., Salluzzo M.G., Castellano S., Signorelli M., Nicoletti F., Di Nuovo S., Drago F., Caraci F. (2013): Role of the transforming-growth-factor-β1 gene in lateonset Alzheimer's disease: implications for the treatment. Current Genomics 14: 147156. 304. Lupo G., Motta C., Giurdanella G., Anfuso C.D., Alberghina M., Drago F., Salomone S., Bucolo C. (2013): Role of phospholipases A2 in diabetic retinopathy: in vitro and in vivo studies. Biochemical Pharmacology doi:pii: S0006-2952(13)00580-7. 303. Caraci F., Castellano S., Salomone S., Drago F., Bosco P., Di Nuovo S. (2013): Searching for disease-modifying drugs in AD: can we combine neuropsychological tools with biological markers? CNS and Neurological Disorders - Drug Targets Aug 27. 302. Salemi M., Barone C., Romano C., Salluzzo R., Caraci F., Cantarella R.A., Salluzzo M.G., Drago F., Romano C., Bosco P. (2013): Pericentrin expression in Down's syndrome. Neurological Sciences Aug 27. 301. Platania C.B., Leggio G.M., Drago F., Salomone S., Bucolo C. (2013): Regulation of intraocular pressure in mice: Structural analysis of dopaminergic and serotonergic systems in response to cabergoline. Biochemical Pharmacology doi:pii: S0006 2952(13)00496-6. 300. Foresti R., Bains S.K., Pitchumony T.S., de Castro Brás L.E., Drago F., Dubois-Randé J.L., Bucolo C., Motterlini R. (2013): Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate hemeb metabolism and inflammation in BV2 microglia cells. Pharmacological Research doi: 10.1016/j.phrs.2013.07.010. 299. Caraci F., Bosco P., Leggio G.M., Malaguarnera M., Drago F., Bucolo C., Salomone S. (2013): Clinical pharmacology of novel anti-Alzheimer disease modifying medications. Current Topics in Medicinal Chemistry 13: 1853-1863. 298. Castorina A., D'Amico A.G., Scuderi S., Leggio G.M., Drago F., D'Agata V. (2013): Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus. Neuroscience doi: 10.1016/j.neuroscience.2013.07.053. 297. D'Amico A.G., Scuderi S., Saccone S., Castorina A., Drago F., D'Agata V. (2013): Antiproliferative effects of PACAP and VIP in serum-starved glioma cells. Journal of Molecular Neuroscience doi: 10.1007/s12031-013-0076-7. 296. Leggio G.M., Salomone S., Bucolo C., Platania C., Micale V., Caraci F., Drago F. (2013): Dopamine D3 receptor as a new pharmacological target for the treatment of depression. European Journal of Pharmacology doi:pii: S0014-2999(13)00544-X. 295. Malaguarnera G., Gagliano C., Bucolo C., Vacante M., Salomone S., Malaguarnera M., Leonardi D.G., Motta M., Drago F., Avitabile T. (2013): Lipoprotein(a) serum levels in diabetic patients with retinopathy. Biomed Research International doi: 10.1155/2013/943505. 10 294. Malaguarnera M., Drago F., Malaguarnera G., Li Volti G., Salomone S., Caraci F., Galvano F., Vacante M., Bucolo C., Malaguarnera M. (2013): Metal fume fever. The Lancet doi: 10.1016/S0140-6736(13)60689-3. 293. Caraci F., Drago F. (2013): New definition of addiction proposed by the American Society of Addiction Medicine: which implications for the treatment of tobacco dependence? European Neuropsychopharmacology doi:pii: S0924-977X(13)00147-8. 292. Bucolo C., Marrazzo G., Platania C.B., Drago F., Leggio G.M., Salomone S. (2013): Fortified extract of red berry, Ginkgo biloba, and white willow bark in experimental early diabetic retinopathy. Journal of Diabetes Research doi: 10.1155/2013/432695. 291. Grosso G., Galvano F., Mistretta A., Marventano S., Nolfo F., Calabrese G., Buscemi S., Drago F., Veronesi U., Scuderi A. (2013): Red orange: experimental models and epidemiological evidence of its benefits on human health. Oxidative Medicine and Cellular Longevity doi: 10.1155/2013/157240. 290. Micale V., Di Marzo V., Sulcova A., Wotjak C.T., Drago F. (2013): Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacology and Therapeutics 138: 18-37. 289. Carta M.G., Aguglia E., Caraci F., Dell'Osso L., Sciascio G.D., Drago F., Giudice E.D., Faravelli C., Hardoy M.C., Lecca M.E., Moro M.F., Calò S., Casacchia M., Angermeyer M., Balestrieri M. (2012): Quality of life and urban / rural living: preliminary results of a community survey in Italy. Clinical Practice and Epidemiology in Mental Health 8: 169-174. 288. D'Amico A.G., Castorina A., Leggio G.M., Drago F., D'Agata V. (2013): Hippocampal neurofibromin and amyloid precursor protein expression in dopamine D3 receptor knock-out mice following passive avoidance conditioning. Neurochemical Research 38: 564-572. 287. Sinagra T., Tamburella A., Urso V., Siarkos I., Drago F., Bucolo C., Salomone S. (2013): Reversible inhibition of vasoconstriction by thiazolidinediones related to PI3K/Akt inhibition in vascular smooth muscle cells. Biochemical Pharmacology 85: 551-559. 286. Biondi A., Malaguarnera G., Vacante M., Berretta M., D'Agata V., Malaguarnera M., Basile F., Drago F., Bertino G. (2012): Elevated serum levels of chromogranin A in hepatocellular carcinoma. BMC Surgery 12 Suppl 1: S7. 285. Frazzetto P., Vacante M., Malaguarnera M., Vinci E., Catalano F., Cataudella E., Drago F., Malaguarnera G., Basile F., Biondi A. (2012): Depression in older breast cancer survivors. BMC Surgery 12 Suppl 1: S14. 284. Vacante M., D'Agata V., Motta M., Malaguarnera G., Biondi A., Basile F., Malaguarnera M., Gagliano C., Drago F., Salomone S. (2012): Centenarians and supercentenarians: a black swan. Emerging social, medical and surgical problems. BMC Surgery 12 Suppl 1: S36. 11 283. Uccello M., Malaguarnera G., Basile F., D'agata V., Malaguarnera M., Bertino G., Vacante M., Drago F., Biondi A. (2012): Potential role of probiotics on colorectal cancer prevention. BMC Surgery 12 Suppl 1: S35. 282. Vitale D.C., Piazza C., Melilli B., Drago F., Salomone S. (2013): Isoflavones: estrogenic activity, biological effect and bioavailability. European Journal of Drug Metabolism and Pharmacokinetics 38: 15-25. 281. Di Rosa M., Malaguarnera G., De Gregorio C., Drago F., Malaguarnera L. (2013): Evaluation of CHI3L-1 and CHIT-1 expression in differentiated and polarized macrophages. Inflammation 36: 482-492. 280. Bucolo C., Drago F., Salomone S. (2012): Ocular drug delivery: a clue from nanotechnology. Frontiers in Pharmacology 3: 188. 279. Bucolo C., Drago F., Salomone S. (2012): Potential drug mechanism(s) targeting the contractile status of hepatic stellate cells. Frontiers in Pharmacology 3: 187. 278. Musumeci T, Bucolo C, Carbone C, Pignatello R, Drago F, Puglisi G. (2013): Polymeric nanoparticles augment the ocular hypotensive effect of melatonin in rabbits. International Journal of Pharmaceutics 440: 135-140. 277. Bucolo C, Salomone S, Drago F, Reibaldi M, Longo A, Uva MG. (2013): Pharmacological management of ocular hypertension: current approaches and future prospective. Current Opinion in Pharmacology 13: 50-55. 276. Platania C.B., Salomone S., Leggio G.M., Drago F., Bucolo C. (2012): Homology modeling of dopamine D2 and D3 receptors: molecular dynamics refinement and docking evaluation. PLoS One 7: e44316. 275. Caraci F., Leggio G.M., Drago F., Salomone S. (2013): Epigenetic drugs for Alzheimer's disease: hopes and challenges. British Journal of Clinical Pharmacology 75: 1154-1155. 274. Amadio M., Osera C., Lupo G., Motta C., Drago F., Govoni S., Pascale A. (2012): Protein kinase C activation affects, via the mRNA-binding Hu-antigen R/ELAV protein, vascular endothelial growth factor expression in a pericytic/endothelial coculture model. Molecular Vision 18: 2153-2164. 273. Bucolo C., Longo L., Camillieri G., Drago F., Salomone S. (2012): Safety profile assessment of buflomedil: an overview of adverse reactions between 1975 and 2011. Pharmacoepidemiology and Drug Safety 21:1190-1196. 272. Giunta S., Castorina A., Bucolo C., Magro G., Drago F., D'Agata V. (2012): Early changes in pituitary adenylate cyclase-activating peptide, vasoactive intestinal peptide and related receptors expression in retina of streptozotocin-induced diabetic rats. Peptides 37: 32-39. 271. Tamburella A., Leggio G.M., Micale V., Navarria A., Bucolo C., Cicirata V., Drago 12 F., Salomone S. (2013): Behavioural and neurochemical changes induced by stressrelated conditions are counteracted by the neurokinin-2 receptor antagonist saredutant. International Journal of Neuropsychopharmacology 16: 813-823. 270. Scapagnini G., Davinelli S., Drago F., De Lorenzo A., Oriani G. (2012): Antioxidants as antidepressants: fact or fiction? CNS Drugs 26: 477-490. 269. Vecchio M., Malaguarnera G., Giordano M., Malaguarnera M., Li Volti G., Galvano F., Drago F., Basile F., Malaguarnera M. (2012): A musician's dystonia. The Lancet 379: 2116. 268. Bucolo C., Leggio G.M., Drago F., Salomone S. (2012): Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats. Biochemical Pharmacology 84: 88-92. 267. Pascale A., Drago F., Govoni S. (2012): Protecting the retinal neurons from glaucoma: lowering ocular pressure is not enough. Pharmacological Research 66: 19-32. 266. Tamburella A., Micale V., Mazzola C., Salomone S., Drago F. (2012): The selective norepinephrine reuptake inhibitor atomoxetine counteracts behavioral impairments in trimethyltin-intoxicated rats. European Journal of Pharmacology 683: 148-154. 265. Bucolo C., Leggio G.M., Maltese A., Castorina A., D'Agata V., Drago F. (2012): Dopamine-₃ receptor modulates intraocular pressure: implications for glaucoma. Biochemical Pharmacology 83: 680-686. 264. Salomone S., Drago F. (2012): Effects of PPARγ ligands on vascular tone. Current Molecular Pharmacology 5: 282-291. 263. Bucolo C., Melilli B., Piazza C., Zurria M., Drago F. (2011): Ocular pharmacokinetics profile of different indomethacin topical formulations. Journal of Ocular Pharmacology and Therapeutics 27: 571-576. 262. Salomone S., Caraci F., Leggio G.M., Fedotova J., Drago F. (2012): New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs. British Journal of Clinical Pharmacology 73: 504-517. 261. Carta M.G., Aguglia E., Balestrieri M., Calabrese J.R., Caraci F., Dell'Osso L., Di Sciascio G., Drago F., Faravelli C., Lecca M.E., Moro M.F., Nardini M., Palumbo G., Hardoy M.C. (2012): The lifetime prevalence of bipolar disorders and the use of antidepressant drugs in bipolar depression in Italy. Journal of Affective Disorders 136: 775-780. 260. Carta M.G., Tondo L., Balestrieri M., Caraci F., Dell'Osso L., Di Sciascio G., Faravelli C., Hardoy M.C., Lecca M.E., Moro M.F., Bhat K.M., Casacchia M., Drago F. (2011): Sub-threshold depression and antidepressants use in a community sample: searching anxiety and finding bipolar disorder. BMC Psychiatry 11: 164. 259. Caraci F., Bosco P., Signorelli M., Spada R.S., Cosentino F.I., Toscano G., Bonforte C., Muratore S., Prestianni G., Panerai S., Giambirtone M.C., Gulotta E., Romano C., 13 Salluzzo M.G., Nicoletti F., Copani A., Drago F., Aguglia E., Ferri R. (2012): The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer's disease and is associated with AD-related depression. European Neuropsychopharmacology 22: 281-289. 258. Terzian A.L., Drago F., Wotjak C.T., Micale V. (2011): The dopamine and cannabinoid interaction in the modulation of emotions and cognition: assessing the role of cannabinoid CB1 receptor in neurons expressing dopamine D1 receptors. Frontiers in Behavioral Neuroscience 5:49. 257. Caraci F., Spampinato S., Sortino M.A., Bosco P., Battaglia G., Bruno V., Drago F., Nicoletti F., Copani A. (2012): Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection. Cell and Tissue Research 347: 291-301. 256. Bucolo C., Musumeci M., Musumeci S., Drago F. (2011): Acidic mammalian chitinase and the eye: implications for ocular inflammatory diseases. Frontiers in Pharmacology 2:43. 255. Marrazzo G., Bellner L., Halilovic A., Li Volti G., Drago F., Dunn M.W., Schwartzman M.L. (2011): The role of neutrophils in corneal wound healing in HO-2 null mice. PLoS One 6: e21180. 254. Melilli B., Piazza C., Vitale D.C., Marano M.R., Pecori A., Mattana P., Volsi V.L., Iuculano C., Cardì F., Drago F. (2011): Human pharmacokinetics of the muscle relaxant, eperisone hydrochloride by liquid chromatography-electrospray tandem mass spectrometry. European Journal of Drug Metabolism and Pharmacokinetics 36: 7178. 253. Caraci F., Crupi R., Drago F., Spina E. (2011): Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract. Current Drug Metabolism 12: 570-577. 252. Bucolo C., Drago F. (2011): Carbon monoxide and the eye: Implications for glaucoma therapy. Pharmacology and Therapeutics 130: 191-201. 251. Li Volti G., Zappalà A., Leggio G.M., Mazzola C., Drago F., La Delia F., Serapide M.F., Pellitteri R., Giannone I., Spatuzza M., Cicirata V., Cicirata F. (2011): Tin chloride enhances parvalbumin-positive interneuron survival by modulating heme metabolism in a model of cerebral ischemia. Neuroscience Letters 492: 33-38. 250. Carta M.G., Aguglia E., Bocchetta A., Balestrieri M., Caraci F., Casacchia M., Dell'osso L, Sciascio G.D., Drago F., Faravelli C., Lecca M.E., Moro M.F., Morosini P.L., Nardini M., Palumbo G., Hardoy M.C. (2010): The use of antidepressant drugs and the lifetime prevalence of major depressive disorders in Italy. Clinical Practice and Epidemiology in Mental Health 6: 94-100. 249. Castorina A., Leggio G.M., Giunta S., Magro G., Scapagnini G., Drago F., D'Agata V. (2011): Neurofibromin and amyloid precursor protein expression in dopamine D3 receptor knock-out mice brains. Neurochemical Research 36: 426-434. 14 248. Caraci F., Molinaro G., Battaglia G., Giuffrida M.L., Riozzi B., Traficante A., Bruno V., Cannella M., Merlo S., Wang X., Heinz B.A., Nisenbaum E.S., Britton T.C., Drago F., Sortino M.A., Copani A., Nicoletti F. (2011): Targeting group-II metabotropic glutamate receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective. Molecular Pharmacology 79: 618-626. 247. 1. Siarkos I., Urso V., Sinagra T., Drago F., Salomone S. (2011): Endothelium-dependent vasomotor effects of telmisartan in isolated rat femoral arteries. Pharmacological Research 63:199-206. 2. 246. 3. Drago F., Bucolo C. (2010): Therapeutic potential of nitric oxide modulation in ocular diseases. Drug News and Perspectives 23: 430-437. 4. 245. 5. Viola S., Merlo S., Consoli G.M., Drago F., Geraci C., Sortino M.A. (2010): Modulation of C6 glioma cell proliferation by ureido-calix[8]arenes. Pharmacology 86: 182-188. 6. 244. 7. Kasper S., Caraci F., Forti B., Drago F., Aguglia E. (2010): Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression. European Neuropsychopharmacology 20: 747-765. 8. 243. Mancardi G.L., Tedeschi G., Amato M.P., D'Alessandro R., Drago F., Milanese C., Popoli P., Rossi P., Savettieri G., Tola M.R., Comi G., Pozzilli C., Bertolotto A., Marrosu M.G., Grimaldi L.M., Laroni A., Vanacore N., Covezzoli A., De Rosa M., Piccinni C., Montanaro N., Periotto L., Iommelli R., Tomino C., Provinciali L. (2011): Three years of experience: the Italian registry and safety data update. Neurological Sciences 31 Suppl 3: 295-297. 242. 9. Leggio G.M., Micale V., Le Foll B., Mazzola C., Nobrega J.N., Drago F. (2011): Dopamine D(3) receptor knock-out mice exhibit increased behavioral sensitivity to the anxiolytic drug diazepam.. European Neuropsychopharmacology 21: 325-332. 10. 241. Amadio M., Bucolo C., Leggio G.M., Drago F., Govoni S., Pascale A. (2010): The PKCbeta/HuR/VEGF pathway in diabetic retinopathy. Biochemical Pharmacology 80: 1230-1207. 11. 240. 12. Tamburella A., Micale V., Leggio G.M., Drago F. (2010): The beta3 adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes. European Neuropsychopharmacology 20: 704-713. 13. 239. 14. Micale V., Cristino L., Tamburella A., Petrosino S., Leggio G.M., Di Marzo V., Drago F. (2010): Enhanced cognitive performance of dopamine D3 receptor "knock-out" mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems. Pharmacological Research 61: 531-536. 15. 238. 16. Stagni E., Bucolo C., Motterlini R., Drago F. (2010): Morphine-induced ocular hypotension is modulated by nitric oxide and carbon monoxide: role of mu3 receptors. Journal of Ocular Pharmacology and Therapeutics 26: 31-35. 15 17. 237. Tempera G., Furneri P.M., Cianci A., Incognito T., Marano M.R., Drago F. (2009): The impact of prulifloxacin on vaginal lactobacillus microflora: an in vivo study Journal of Chemotherapy 21: 646-650. 18. 236. 19. Bondì M.L., Craparo E.F., Giammona G., Drago F. (2010): Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution. Nanomedicine (London) 5: 25-32. 20. 235. 21. Caraci F., Battaglia G., Bruno V., Bosco P., Carbonaro V., Giuffrida M.L., Drago F., Sortino M.A., Nicoletti F., Copani A. (2009): TGF-beta1 pathway as a new target for neuroprotection in Alzheimer's Disease. CNS Neuroscience and Therapeutics 17: 237249. 22. 234. Tedeschi G., Amato M.P., D'Alessandro R., Drago F., Milanese C., Popoli P., Rossi P., Savettieri G., Tola M.R., Vanacore N., Covezzoli A., De Rosa M., Comi G., Pozzilli C., Bertolotto A., Marrosu M.G., Grimaldi L.M., Piccinni C., Montanaro N., Periotto L., Iommelli R., Addis A., Martini N., Provinciali L., Mancardi G.L. (2009): The pharmacovigilance program on natalizumab in Italy: 2 years of experience. Neurological Sciences 30 Suppl 2: S163-165. 23. 233. 24. Caraci F., Copani A., Nicoletti F., Drago F. (2010): Depression and Alzheimer's disease: neurobiological links and common pharmacological targets. European Journal of Pharmacology 626: 64-71. 25. 232. 26. Leggio G.M., Cathala A., Neny M., Rouge-Pont F., Drago F., Piazza P.V., Spampinato U. (2009): In vivo evidence that constitutive activity of serotonin(2C) receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. Journal of Neurochemistry 111: 614-623. 27. 231. 28. Bucolo C, Drago F. (2009): Focus on molecules: heme oxygenase-1. Experimental Eye Research 89: 822-823. 230. Tamburella A., Micale V., Navarria A., Drago F. (2009): Antidepressant properties of the 5-HT(4) receptor partial agonist, SL65.0155: Behavioral and neurochemical studies in rats. Progress in Neuropsychopharmacology and Biological Psychiatry 33: 12051210. 229. Micale V., Cristino L., Tamburella A., Petrosino S., Leggio G.M., Drago F., Marzo V.D. (2009): Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems. Neurobiology of Diseases 36: 70-80. 228. Mazzola C., Medalie J., Scherma M., Panlilio L.V., Solinas M., Tanda G., Drago F., Cadet J.L., Goldberg S.R., Yasar S. (2009): Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors. Learning and Memory 29: 332-337. 16 227. Fumagalli F., Pasini M., Frasca A., Drago F., Racagni G., Riva M.A. (2009): Prenatal stress alters glutamatergic system responsiveness in adult rat prefrontal cortex. Journal of Neurochemistry 109: 1733-1744. 226. Bucolo C., Ward K.W., Mazzon E., Cuzzocrea S., Drago F. (2009): Protective effects of a coumarin derivative in diabetic rats. Investigative Ophthalmology and Visual Sciences 50: 3846-3852. 225. Chiechio S., Zammataro M., Morales M.E., Busceti C.L., Drago F., Gereau R.W., Copani A., Nicoletti F. (2009): Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain. Molecular Pharmacology 75: 1014-1020. 224. Consoli D., Contarino A., Tabarin A., Drago F. (2009): Binge-like eating in mice. International Journal of Eating Disorders 42: 402-408. 223. Carbonaro V., Caraci F., Giuffrida M.L., Merlo S., Canonico P.L., Drago F., Copani A., Sortino M.A. (2009): Enhanced expression of ERalpha in astrocytes modifies the response of cortical neurons to beta-amyloid toxicity. Neurobiology of Diseases 33: 415-421. 222. Panlilio L.V., Mazzola C., Medalie J., Hahn B., Justinova Z., Drago F., Cadet J.L., Yasar S., Goldberg S.R. (2009): Anandamide-induced behavioral disruption through a vanilloid-dependent mechanism in rats. Psychopharmacology (Berl.) 203: 529-538. 221. Stagni E., Privitera M.G., Bucolo C., Leggio G.M., Motterlini R., Drago F. (2009): A water-soluble carbon monoxide-releasing molecule (CORM-3) lowers intraocular pressure in rabbits. British Journal of Ophthalmology 93: 254-257. 220. Mancardi GL, Amato MP, D'Alessandro R, Drago F, Milanese C, Popoli P, Provinciali L, Rossi P, Savettieri G, Tedeschi G, Tola MR, Vanacore N, Covezzoli A, De Rosa M, Piccinni C, Montanaro N, Periotto L, Addis A, Martini N. (2008): Natalizumab: a country-based surveillance program. Neurological Sciences 29 Suppl 2: S235-7. 219. Viola S., Consoli G.M., Merlo S., Drago F., Sortino M.A., Geraci C. (2008): Inhibition of rat glioma cell migration and proliferation by a calix[8]arene scaffold exposing multiple GlcNAc and ureido functionalities. Journal of Neurochemistry 107: 10471055. 218. Marcellino D., Ferré S., Casadó V., Cortés A., Le Foll B., Mazzola C., Drago F., Saur O., Stark H., Soriano A., Barnes C., Goldberg S.R., Lluis C., Fuxe K., Franco R. (2008): Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. Journal of Biological Chemistry 19: 26016-26025 217. D'Agata V., Tiralongo A., Castorina A., Leggio G.M., Micale V., Carnazza M.L., Drago F. (2008): Parkin expression profile in dopamine D3 receptor knock-out mice brains. Neurochemistry Research 34: 327-332. 216. Micale V., Cristino L., Tamburella A., Petrosino S., Leggio G.M., Drago F., Di Marzo 17 V. (2008): Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels. Neuropsychopharmacology 34: 593-606. 215. Micale V, Tamburella A, Leggio GM, Mazzola C, Li Volsi V, Drago F. (2008): Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions. Pharmacology Biochemistry and Behavior 90: 463-469. 214. Molteni R., Pasini M., Moraschi S., Gennarelli M., Drago F., Racagni G., Riva M.A. (2008): Reduced activation of intracellular signaling pathways in rat prefrontal cortex after chronic phencyclidine administration. Pharmacological Research 57: 296-302. 213. Caraci F., Battaglia G., Busceti C., Biagioni F., Mastroiacovo F., Bosco P., Drago F., Nicoletti F., Sortino M.A., Copani A. (2008): TGF-beta1 protects against A betaneurotoxicity via the phosphatidylinositol-3-kinase pathway. Neurobiology of Diseases 30: 234-242. 212. Bucolo C., Musumeci M., Maltese A., Drago F., Musumeci S. (2008): Effect of chitinase inhibitors on endotoxin-induced uveitis (EIU) in rabbits. Pharmacological Research 57: 247-252. 211. Micale V., Scapagnini G., Colombrita C., Mazzola C., Alkon D.L., Drago F. (2008): Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks. European Neuropsychopharmacology 18: 462-471. 210. Amadio M., Scapagnini G., Lupo G., Drago F., Govoni S., Pascale A. (2008) PKCbetaII/HuR/VEGF: A new molecular cascade in retinal pericytes for the regulation of VEGF gene expression. Pharmacological Research 57: 60-66. 209. Genazzani A.A., Biggio G., Caputi A.P., Del Tacca M., Drago F., Fantozzi R., Canonico P.L. (2007): Biosimilar drugs: Concerns and opportunities. Biodrugs 21: 351-356. 208. Tabarin A., Diz-Chaves Y., Consoli D., Monsaingeon M.,.Bale T.L., Culler M.D., Datta R., Drago F., Vale W.W., Koob G.F., Zorrilla E.P., Contarino A. (2007): Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis. European Journal of Neuroscience 26: 2303-2314. 207. Micale V., Mazzola C., Drago F. (2007): Endocannabinoids and neurodegenerative diseases. Pharmacological Research 56: 382-392. 206. Drago F. (2007): Endocannabinoids and psychopathology: The therapy inside. Pharmacological Research 56: 357-359. 205. Piazza C., Privitera M.G., Melilli B., Incognito T., Marano M.R., Leggio G.M., Roxas M.A., Drago F. (2007): Influence of inulin on plasma isoflavone concentrations in healthy postmenopausal women. American Journal of Clinical Nutrition 86: 775-780. 204. Leggio G.M., Micale V., Drago F. (2008): Increased sensitivity to antidepressants of D(3) dopamine receptor-deficient mice in the forced swim test (FST). European 18 Neuropsychopharmacology 18: 271-277. 203. Consoli D., Leggio G.M., Mazzola C., Micale V., Drago F. (2007): Behavioral effects of the β3 adrenoceptor agonist SR58611A: Is it the putative prototype of a new class of antidepressant/anxiolytic drugs? European Journal of Pharmacology 573: 139-147. 202. Privitera M.G., Potenza M., Bucolo C., Leggio G.M., Drago F. (2007) Hemin, an inducer of heme oxygenase-1, lowers intraocular pressure in rabbits. Journal of Ocular Pharmacology and Therapeutics 23: 232-239. 201. Barbiero V.S., Giambelli R., Musazzi L., Tiraboschi E., Tardito D., Perez J., Drago F., Racagni G., Popoli M. (2007): Chronic antidepressants induce redistribution and differential activation of alphaCaM kinase II between presynaptic compartments. Neuropsychopharmacology 32: 2511-2519. 200. Bucolo C., Drago F. (2007): Neuroactive steroids protect retinal tissue through sigma1 receptors. Basic and Clinical Pharmacology and Toxicology 100: 214-216. 199. Leggio G.M., Incognito T., Privitera G., Marano M.R., Drago F. (2006): Comparative bioavailability of different formulations of levothyroxine and liothyronine in healthy volunteers. Journal of Endocrinological Investigations 29: 35-38. 198. Neri P.G., Stagni E., Filippello M., Camillieri G., Giovannini A., Leggio G.M., Drago F. (2006): Oral Echinacea purpurea extract in low-grade, steroid-dependent, autoimmune idiopathic uveitis: a pilot study. Journal of Ocular Pharmacology and Therapeutics 22: 431-436. 197. Micale V., Leggio G.M., Mazzola C., Drago F. (2006): Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia. Brain Research 1121: 207-215. 196. Bonfiglio V., Camillieri G., Avitabile T., Leggio G.M., Drago F. (2006): Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: role of nitric oxide. Experimental Eye Research 83: 1366-1372. 195. Van der Stelt M., Mazzola C., Esposito G., Matias I., Petrosino S., Filippis D.D., Micale V., Steardo L., Drago F., Iuvone T., Di Marzo V. (2006): Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. Cellular and Molecular Life Sciences 29: 1410-1424. 194. Lo Pumo R., Bellia M., Nicosia A., Micale V., Drago F. (2006): Long-lasting neurotoxicity of prenatal benzene acute exposure in rats. Toxicology 15: 227-234. 193. Bucolo C., Marrazzo A., Ronsisvalle S., Ronsisvalle G., Cuzzocrea S., Mazzon E., Caputi A., Drago F. (2006): A novel adamantane derivative attenuates retinal ischemiareperfusion damage in the rat retina through sigma1 receptors. European Journal of Pharmacology 536: 200-203. 192. Micale V., Arezzi A., Rampello L., Drago F. (2006): Melatonin affects the immobility time of rats in the forced swim test: The role of serotonin neurotransmission. European Neuropsychopharmacology 16: 538-545. 19 191. Bonfiglio V., Bucolo C., Camillieri G., Drago F. (2006): Possible involvement of nitric oxide in morphine-induced miosis and reduction of intraocular pressure in rabbits. European Journal of Pharmacology 534: 227-232. 190. Bucolo C., Drago F., Lin L.R., Reddy V.N. (2006): Sigma receptor ligands protect human retinal cells against oxidative stress. Neuroreport 17: 287-291. 189. Fumagalli F., Frasca A., Spartà M., Drago F., Racagni G., Riva M.A. (2006): Longterm exposure to the atypical antipsychotic olanzapine differently up-regulates extracellular signal-regulated kinases 1 and 2 phosphorylation in subcellular compartments of rat prefrontal cortex. Molecular Pharmacology 69: 1366-1372. 188. Micale V., Incognito T., Ignoto A., Rampello L., Spartà M., Drago F. (2005): Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury. European Neuropsychopharmacology 219: 123-126. 187. Consoli D., Fedotova J., Micale V., Sapronov N.S., Drago F. (2005): Stressors affect the response of male and female rats to clomipramine in a model of behavioral despair (forced swim test). European Journal of Pharmacology 520: 100-107. 186. Bucolo C., Drago F., Lin L.R., Reddy V.N. (2005): Neuroactive steroids protect retinal pigment epithelium against oxidative stress. Neuroreport 16: 1203-1207. 185. Maltese A., Maugeri F., Drago F., Bucolo C. (2005): Simple determination of riluzole in rat brain by high-performance liquid chromatography and spectrophotometric detection. Journal of Chromatography Bio Analytical Technology and Biomedical Life Sciences 817: 331-334. 184. Camillieri G., Bucolo C., Rossi S., Drago F. (2005): Hyaluronan-induced stimulation of corneal wound healing is a pure pharmacological effect. Journal of Ocular Pharmacology and Therapeutics 20: 548-553. 183. Bucolo C., Drago F. (2004): Effects of neurosteroids on ischemia-reperfusion injury in the rat retina: role of sigma1 recognition sites. European Journal of Pharmacology 498: 111-114. 182. Camillieri G., Nastasi A., Gulino P., Bucolo C., Drago F. (2004): Effects of hyaluronan on free-radical formation, corneal endothelium damage, and inflammation parameters after phacoemulsification in rabbits. Journal of Ocular Pharmacology and Therapeutics 20: 151-157. 181. Medico M., Nicosia A., Grech M., Onesta M., Sessa G., Rampello L., Drago F. (2004): Riluzole restores motor activity in rats with post-traumatic peripheral neuropathy. Neuroscience Letters 358: 37-40. 180. Giuffrida S., Bucolo C., Drago F. (2003): Topical application of a nitric oxide synthase inhibitor reduces intraocular pressure in rabbits with experimental glaucoma. Journal of Ocular Pharmacology and Therapeutics 19: 527-534. 179. Mazzola C., Micale V., Drago F. (2003): Amnesia induced by β-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade. European Journal of 20 Pharmacology 477: 219-225. 178. Castorina M., Marino R., Grassi M., Drago F. (2003): Very low doses of ethanol induce behavioral changes involving dopamine D2 receptors. European Journal of Pharmacology 477: 129-135. 177. Nicosia A., Giardina L., Di Leo F., Medico M., Mazzola C., Genazzani A.A., Drago F. (2003): Long-lasting behavioral changes induced by pre- or neonatal exposure to diazepam in rats. European Journal of Pharmacology 469: 103-109. 176. Drago F., Macauda S., Salehi S. (2002): Small doses of melatonin increase intestinal motility in rats. Digestive Disease Science 47: 1969-1974. 175. Stjernschantz J.W., Albert D.M., Hu D.N., Drago F., Wistrand P.J. (2002): Mechanism and clinical significance of prostaglandin-induced iris pigmentation. Survey of Ophthalmology 47 Suppl 1: S162-175. 174. Medico M., De Vivo S., Tomasello C., Grech M., Nicosia A., Castorina M., D'Agata M.A., Rampello L., Lempereur L., Drago F. (2002): Behavioral and neurochemical effects of dopaminergic drugs in models of brain injury. European Neuropsychopharmacology 12: 187-194. 173. Drago F., Floriddia M.L., Cro M., Giuffrida S. (2002): Pharmacokinetics and bioavailability of a Ginkgo biloba extract. Journal of Ocular Pharmacology and Therapeutics 18: 197-202. 172. Drago F., Nicolosi A., Micale V., Lo Menzo G. (2001): Placebo affects the performance of rats in models of depression: is it a good control for behavioral experiments? European Neuropsychopharmacology 11: 209-213. 171. Floriddia M.L., Castorina M., Drago F. (2000): Comparative bioavailability of a new formulation of fluoxetine drops. European Review of Medical and Pharmacological Sciences 4: 9-13. 170. Drago F., Valzelli S., Emmi I., Marino A., Cassar Scalia C., Marino V. (2001): Latanoprost exerts neuroprotective activity in vitro and in vivo. Experimental Eye Research 72: 479-486. 169. Drago F., Frisina M., Grech M., Nicolosi A., Micale V., Nicosia A., Medico M., Foti F. (2001): Dual effects of melatonin on barbiturate-induced narcosis in rats. Neuroscience Letters 300: 176-178. 168. Drago F., Arezzi A., Virzi A. (2000): Effects of acute or chronic administration of substituted benzamides in experimental models of depression in rats. European Neuropsychopharmacology 10: 437-442. 167. Drago F., Lissandrello C.O. (2000): The “low dose” concept and the paradoxical effects of prolactin on grooming and sexual behavior. European Journal of Pharmacology 405: 131-137. 166. Drago F., Busà L. (2000): Acute low doses of melatonin restore full sexual activity in 21 impotent male rats. Brain Research 878: 98-104. 165. Clementi G., Floriddia M.L., Prato A., Marino A., Drago F. (2000): Adrenomedullin and ocular inflammation in the rabbit. European Journal of Pharmacology 400: 321326. 164. Drago F., Busà L., Benelli A., Bertolini A. (1999): Acute low doses of melatonin stimulate rat sex behavior: the role of serotonin neurotransmission. European Journal of Pharmacology 385: 1-6. 163. Clementi G., Busà L., De Bernardis E., Prato A., Drago F. (1999): Effects of centrally injected amylin on sexual behavior of male rats. Peptides 20: 379-382. 162. Rampello L., Drago F. (1999): Nicergoline facilitates vestibular compensation in aged male rats with unilateral labyrinthectomy. Neuroscience Letters 267: 93-96. 161. Drago F., Montoneri C., Varga C., Laszlo F. (1999): Dual effect of female sex steroids on drug-induced gastroduodenal ulcers in the rat. Life Sciences 64: 2341-2350. 160. Contarino A., Drago F., Zanotti A., Natolino F., Berti T., Giusti P. (1999): A new place conditioning paradigm to study tolerance to opiates in mice. Neuroreport 10: 517-521. 159. Drago F., Di Leo F., Giardina L. (1999): Prenatal stress induces body weight deficit and behavioural alterations in rats: the effect of diazepam. European Neuropsychopharmacology 9: 239-245. 158. Drago F., Contarino A., Busà L. (1999): The expression of neuropeptide-induced excessive grooming behavior in dopamine D1 and D2 receptor-deficient mice. European Journal of Pharmacology 365: 125-131. 157. Drago F., Marino A., La Manna C. (1999): α-Methyl-p-tyrosine inhibits latanoprostinduced melanogenesis in vitro. Experimental Eye Research 68: 85-90. 156. Drago F., La Manna C., Marino V., Marino A., Emmi I., Reibaldi A. (1998): Norfloxacin exhibits negligible serum concentrations after repeated conjunctival instillation in children. British Journal of Clinical Pharmacology 46: 272-274. 155. Drago F., La Manna C., Emmi I., Marino A. (1998): Effects of sulfinpyrazone on retinal damage induced by experimental diabetes mellitus in rabbits. Pharmacological Research 38: 97-100. 154. Drago F., Busà L. (1997): Dose-dependent effects of acute kainic acid treatment on sexual behavior of male rats. Brain Research 778: 135-139. 153. Blasco G., Traversa U., Drago F. (1997): Effects of nicergoline on rabbit electroretinogram during recovery after ischaemia in light and dark. Pharmacological Research 36: 363-368. 152. Montoneri C., Drago F. (1997): Effects of pregnancy in rats on cysteamine-induced peptic ulcers: role of progesterone. Digestive Diseases and Sciences 42: 2572-2575. 22 151. Làzlò F., Varga C., Montoneri C., Drago F. (1997): Damaging actions of testosterone on cysteamine-induced gastroduodenal ulceration and vascular leakage in the rat. European Journal of Pharmacology 337: 275-278. 150. Drago F., Montoneri C. (1997): Growth hormone and somatostatin interaction in the ulcerogenic effect of cysteamine in female rats. Journal of Physiology (Paris) 91: 127130. 149. Contarino A., Zanotti A., Drago F., Natolino F., Lipartiti M., Giusti P. (1997): Conditioned place preference: no tolerance to the rewarding properties of morphine. Naunyn Schmiedebergs Archives of Pharmacology 335: 589-594. 148. Drago F., Emmi I., Marino V.(1997): Effects of β-blockers association with pilocarpine on rabbit intraocular pressure and heart rate. Pharmacological Research 35: 299-306. 147. Rampello L., Raffaele R., Nicoletti G., Le Pira F., Vecchio I., Malaguarnera M., Drago F. (1997): Neurobehavioral syndrome induced by H2-receptor blocker withdrawal: possible role of prolactin. Clinical Neuropharmacology 20: 49-54. 146. Drago F., Stanciu M., Salehi S., Scapagnini U. (1997): The block of central vasopressin V1 but not V2 receptors suppresses grooming behavior and hypothermia induced by intracerebroventricular vasopressin in male rats. Peptides 18: 1389-1392. 145. Drago F., Montoneri C. (1997): Influence of growth hormone on cysteamine-induced gastro-duodenal lesions in rats: the involvement of somatostatin. Life Sciences 61: 2128. 144. Drago F., Contarino A., Marino R., Anzallo C., Valerio C., Rampello L., Raffaele R., Scapagnini U. (1997): Effects of acute or chronic administration of risperidone on motor and sexual behavior of male rats. Pharmacological Research 35: 17-25. 143. Cavallaro S., D'Agata V., Drago F., Musco S., Nuciforo G., Ricciardolo F., Travali S., Stivala F., Arimura A., Canonico P.L. (1996): Ocular expression of type-I pituitary adenylate cyclase-activating polypeptide (PACAP) receptors. Annals of the New York Academy of Sciences 805: 555-557. 142. Drago F., Di Leo F., Ikonomou S., Anzallo C., Busà L., Lo Presti L. (1996): Behavioral and endocrine effects of growth hormone administration in aged female rats. Psychoneuroendocrinology 21: 401-410. 141. Drago F., Musco S., Nardo L., Valerio C., Grassi M., Rampello L. (1996): Behavioral and neurochemical alterations induced by reversible conductive hearing loss in aged male rats. Neuroscience Letters 205: 1-4. 140. Drago F., Nardo L., Rampello L., Raffaele R. (1996): Vestibular compensation in aged rats with unilateral labyrinthectomy treated with dopaminergic drugs. Pharmacological Research 33: 135-140. 139. Rampello R., Raffaele R., Nicoletti G., Le Pira F., Malaguarnera M., Drago F. (1996): Histerical neurosis of the conversion type: therapeutic activity of neuroleptics with different hyperprolactinemic potency. Neuropsychobiology 33: 186-188. 23 138. Clementi G., Valerio C., Emmi I., Prato A., Drago F. (1996): Behavioral effects of amylin injected intracerebroventricularly in the rat. Peptides 17: 589-591. 137. Drago F., Coppi G., Antonuzzo P.A., Valerio C., Genazzani A.A., Grassi M., Raffaele R., Scapagnini U. (1996): Effects of RGH 2202 on cognitive and motor behavior of the rat. Neurobiology of Aging 17: 67-71. 136. Drago F., D'Agata V., Marino V., Marino A., Blasco G. (1995): Biochemical changes induced by pyrphenoxone in the lens of rabbits and rats. Pharmacological Research 31: 325-329. 135. Rampello L., Nicoletti G., Raffaele R., Drago F. (1995): Comparative effects of amitriptyline and amineptine in patients affected by anxious depression. Neuropsychobiology 31: 130-134. 134. Drago F, De Bernardis E. (1994): Lachrymal concentration of norfloxacin after a single ocular instillation in humans. European Journal of Ophthalmology 4: 102-104. 133. Falsaperla A., Sicurella L., Abu Zied N., Rampello L., Drago F. (1993): Therapeutic efficacy of a 30-300 KD protein fraction vs. gangliosides in the treatment of diabetic neuropathy. A pilot study. Acta Therapeutica 19: 275-281. 132. Iurato M.P., Chiarenza A., Barbera N., Cantarella G., Lempereur L., Drago F., Scapagnini U., Bernardini R. (1993): Thymic factors influence on behavior in rodents. Pharmacology Biochemistry and Behavior 44: 665-671. 131. D'Agata V., Drago F., Serapide F., Cicirata F. (1993): Effects of cerebellectomy on motivation-related behavior: a time-course study. Physiology and Behavior 53: 173176. 130. Drago F., Mauceri F., Nardo L., Valerio C., Genazzani A.A., Grassi M. (1993): Effects of cytidine-diphosphocholine on acetylcholine-mediated behaviors in the rat. Brain Research Bulletin 31: 485-489. 129. Drago F., Dal Bello A., Marino V., Pisati R., Lodola E., Barbieri P. (1993): Evaluation of the effects of thymoxamine solution 0.5% on mydriasis induced by ibopamine solution 1%. European Journal of Clinical Pharmacology 44: 477-480. 128. Grassi M., Drago F. (1993): Effects of oxytocin on emotional stress and stress-induced gastric lesions. Journal of Physiology (Paris) 87: 261-264. 127. Drago F., Grassi M. Genazzani A.A. (1993): Neuromediators in aging and gastric mucosal injury. Journal of Physiology (Paris) 87: 379-383. 126. Drago F., Mauceri F., Valerio C., Lauria N. (1992): Effects of a protein fraction (m.w. 30-300 KD) on the recovery of sensorimotor function in the rat. Acta Therapeutica 18:75-80. 125. Drago F., Valerio C., Nardo L., Genazzani A.A., D'Agata V., Mauceri F., Freni V. (1992): Cerebral actions of dihydroergocristine. Arzneimittel Forschung Drug Research 42: 1391-1394. 24 124. Raffaele R., Cosentino E., Anicito M.B., Sciacca A., Rampello L., Pennisi G., Genazzani A.A., Bosco G., Casabona A., Drago F. (1992): Effects of TRH-T on spinal motoneurones in man. Neuroreport 3: 1017-1018. 123. Clementi G., Grassi M., Valerio C., Prato A., Fiore C.E., Drago F. (1992): Effects of calcitonin gene-related peptide on extrapyramidal motor system. Pharmacology Biochemistry and Behavior 42: 545-548. 122. Drago F., Mauceri F., Fidilio M., Cavaliere S., Pulvirenti L., Foti F. (1992): Effects of thyrotropin-releasing hormone, oxytocin, and prolactin on thiopenthal-induced narcosis in rats. Brain Research Bullettin 28: 781-783. 121. Drago F. , Agnoli A., Avanzini G. Azzena G.B., Conticello S. De Vincentiis I., Dufour A., Manni E. Mira E., Modugno C. et al. (1992): The definition of a reference protocol for the clinical study of vertigo drugs. Acta Otorhinolaryngologica Italica 12: 303308. 120. Drago F., Mauceri F., Nardo L., Valerio C., Lauria N., Rampello L., Guidi G. (1992): Behavioral effects of l-α-glycerylphosphorylcholine: Influence on cognitive mechanisms in the rat. Pharmacology Biochemistry and Behavior 41: 445-448. 119. Rampello L., Nicoletti G., Drago F. (1991): The dopaminergic hypothesis for hysterical neurosis of the conversion type: a study with sulpiride, haloperidol and amineptine. Acta Therapeutica 17: 195-202. 118. Rampello L., Nicoletti G., Drago F. (1991): Flunarizine-induced extrapyramidal and depressive symptoms: a clinical model of central dopaminergic impairment. Acta Therapeutica 17: 307-310. 117. Raffaele R., Cosentino E., Anicito B., Rampello L., Drago F., Nardo F. (1991): Effects of levocarnitine acetyl on motor disturbances of diabetic rats. Acta Therapeutica 17: 363-367. 116. Drago F., Grassi M., Valerio C., Coppi G., Lauria N., Nicotra G.C., Raffaele R. (1991): Behavioral changes induced by the thyrotropin-releasing hormone analogue, RGH 2202. Peptides 12: 1309-1313. 115. Drago F., Spadaro F., D'Agata V., Valerio C., Grassi M. Mauceri F., Pennisi G., Scapagnini U. (1991): Protective action of phosphatidylserine on stress-induced behavioral and autonomic changes in aged rats. Neurobiology of Aging 12: 437-440. 114. Drago F., Sarnyai Z., D'Agata V. (1991): The inhibition of oxytocin-induced grooming by a specific receptor antagonist. Physiology and Behavior 50: 533-536. 113. Reibaldi A., Spampinato D., Cavaliere S., Rapisarda E., Cavallaro N., Caruso P., Dal Bello A., Drago F. (1991): Effects of Nd-Yag laser vitreolysis on lens and vitreous prostaglandins in the rabbit eye. Metabolic, Pediatric and Systemic Ophthalmology 14: 44-46. 112. Cavaliere S., Spampinato D., Caruso P., Dal Bello A., Reibaldi A., Drago F. (1990): Effects of hyaluronic acid fractions in the rabbit eye. Annals of Ophthalmology 22: 25 429-431. 111. Tassorelli C., Spampinato D., Caruso P., Cavaliere S., Micieli G., Drago F., Nappi G. (1990): Neurotensin-induced miosis: the role of dopaminergic pathways. Peptides 11: 1309-1311. 110. Drago F., Grassi M., Valerio C., Spadaro F., D'Agata V., Lauria N. (1990): Effects of vinburnine on experimental models of learning and memory impairments. Pharmacology Biochemistry and Behavior 37: 53-57. 109. Pulvirenti G., Valerio C., Spadaro F., D'Agata V., Freni V., Nardo L., Drago F. (1990): Acetylcarnitine reduces the immobility of rats in a despair test (constrained swim). Behavioral and Neural Biology 54: 110-114. 108. Spampinato D., Cavaliere S., Dal Bello A., Caruso P., Marino V., Drago F. (1990): Role of D1 and D2 receptors in the regulation of intraocular pressure. Pharmacological Research 22 (suppl. 1): 57-58. 107. Genazzani A.A., Mauceri F., Valerio C., Nardo L., Drago F. (1990): Effects of risperidone on motor and sexual activity in the rat. Pharmacological Research 22 (suppl. 1): 61-62. 106. Drago F., D'Agata V., Valerio C., Spadaro F., Raffaele R., Nardo L., Grassi M., Freni V. (1990): Memory deficits of aged male rats can be improved by pyrimidine nucleosides and n-acetyl-glutamine. Clinical Neuropharmacology 13: 290-296. 105. Drago F., D'Agata V., Spadaro F., Grassi M., Valerio C. (1990): Prolactin as a protective factor in stress-induced gastric ulcers. Annals of the New York Academy of Sciences 597: 248-251. 104. Drago F., Pulvirenti G., Spadaro F., Pennisi G. (1990): Effects of TRH and prolactin in the behavioral despair (swim) model of depression in rats. Psychoneuroendocrinology 15: 349-356. 103. Drago F., Valerio C., D'Agata V., Spadaro F., Astuto C., Manzone G., Lauria N. (1989): Effects of dihydroergocristine on experimental models of vertigo. Acta Therapeutica 15: 385-394. 102. Cavaliere S., Caruso P., Spampinato D., Drago F. (1989): Neurochemical mechanisms of neurotensin-induced miosis. Pharmacological Research 21 (suppl. 1): 49-50. 101. D'Agata V., Spampinato G., Iacona T., Spadaro F., Messina L., Messina A., Drago F. (1989): Effects of TRH on the immune system of newborn rats. Pharmacological Research 21 (suppl. 1): 47-48. 100. Valerio C., Clementi G., Spadaro F., D'Agata V., Raffaele R., Grassi M., Lauria N., Drago F. (1989): The effects of acetyl-l-carnitine on experimental models of learning and memory deficits in the old rat. Functional Neurology 4: 387-390. 99. Clementi G., Valerio C., Prato A., Caruso A., Patti F., Patané S., Drago F. (1989): Effects of calcitonin on morphine tolerance and withdrawal syndrome in morphine 26 physically dependent rats. European Journal of Pharmacology 163: 175-179. 98. Drago F., D'Agata V., Iacona T., Spadaro F., Grassi M., Valerio C., Raffaele R., Astuto C., Lauria N., Vitetta M. (1989): Prolactin as a protective factor in stress-induced biological changes. Journal of Clinical Laboratory Analysis 3: 340-344. 97. Drago F., Gagliano C., Cavaliere S. (1989): Aging related changes of neurotransmitters in the visual system. Metabolic, Pediatric and Systemic Ophthalmology 12: 21-23. 96. Drago F., Spadaro F. and Scapagnini U. (1988): Prolactin affects central dopamine receptor function: The behavioral model of aged rats. Pharmacological Research Communications 20: 1101-1102. 95. D'Agata V., Spadaro F., Drago F. (1988): Dihydroergocristine improves behavioral deficits of aged rats. Pharmacological Research Communications 20:1119-1120. 94. Nicoletti F., Valerio C., Pellegrino C., Drago F., Scapagnini U., Canonico P.L. (1988): Spatial learning potentiates the stimulation of phosphoinositide hydrolysis by excitatory aminoacids in rat hippocampal slices. Journal of Neurochemistry 51: 725729. 93. Drago F., Valerio C., Scalisi B., D'Agata V., Scapagnini U. (1988): Dihydroergocristine and memory alterations of aged male rat. Pharmacology Biochemistry and Behavior 30: 961-965. 92. Drago F., Valerio C., D'Agata V., Lauria N., Scapagnini U. (1988): Dihydroergocryptine improves behavioral deficits of aged male rats. Neurobiology of Aging 9: 285-290. 91. Drago F, Valerio C, D'Agata V, Astuto C, Spadaro F, Continella G, Scapagnini U. (1988): Pyroglutamic acid improves learning and memory capacities in old rats. Functional Neurology 3: 137-143. 90. Pedersen C.A., Caldwell J.D., Drago F., Noonan L.R., Peterson G., Hood L.E., Prange A.J. (1988): Grooming behavioral effects of oxytocin, pharmacology, ontogeny and comparisons with other nonapeptides. Annals of the New York Academy of Sciences 525: 245-256. 89. Drago F. (1988): The role of prolactin in rat grooming behavior. Annals of the New York Academy of Sciences 525: 237-244. 88. Spadaro F., Drago F., Scapagnini U. (1988): The bioinactivation of cerebral TRH by a specific antiserum affects neonatal and adult behavior of the rat. Pharmacological Research Communications 20: 217-218. 87. Aguglia E., Zurria GL., Musmeci G., Drago F., Brambilla F. (1987): Pilot study of the effects of TRH-T on cognitive processes in schizophrenic patients. Acta Therapeutica 13: 141-149. 86. Dal Bello A., Cavaliere S., Spampinato D., Franco L., Caruso P., Gagliano C., Drago F. (1987): Use of hyaluronic acid in radial keratotomy. Acta Therapeutica 13: 379-384. 27 85. Drago F., Continella G., Valerio C., D'Agata V., Astuto C., Spadaro F., Scapagnini U. (1987): Effects of pyroglutamic acid on learning and memory processes of the rat. Acta Therapeutica 13: 587-594. 84. Dal Bello A., Gagliano C., Cavaliere S., Spampinato D., Reibaldi A., Guarcello V., Drago F. (1987): Distribution of rifampicin in ocular tissues after systemic administration. Acta Therapeutica 13: 595-598. 83. Valerio C., D'Agata V., Spadaro F., Astuto C., Lauria N., Drago F. (1987): Effects of betahistine on behavioural alterations induced by hypoxic hypoxia and chronic cerebrovascular insufficiency. Acta Therapeutica 13:5 99-607. 82. Saraniti G., Cavaliere S., Dal Bello A., Spampinato D., Drago F. (1987): Dopaminergic system in the retina of rabbits and its interaction with TRH. Ophtalmologie 1: 515-517. 81. Romano G., Salemi S., Cancemi G., Tripi F., Rasà R., Drago F. (1987): Penetration of labeled rifampicin into the rat parotid gland. European Review of Medical and Pharmacological Sciences 9: 345-347. 80. Drago F., Cavallaro N., Dal Bello A., Cavaliere S., Spampinato D., Gorgone G. (1987): Hyperprolactinaemia increases intraocular pressure in humans. Metabolic, Pediatric and Systemic Ophthalmology 10: 76-78. 79. Valerio C., Auditore S., Spadaro F., Panella P., Franco L., Lauria N., Drago F. (1986): The anti-inflammatory activity of an extract derived from Triticum Vulgare. Acta Therapeutica 12: 171-177. 78 Cavaliere S., Spampinato D., Lauria N., Drago F. (1986): Accelerated recovery of corneal ulcers in rabbits treated with an extract derived from Triticum Vulgare. Acta Therapeutica 12: 179-184. 77. Drago F., Bohus B. (1986): Hyperprolactinaemia alleviates behavioral alterations of rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain). Physiology and Behavior 38: 517-523. 76. Drago F., Valerio C., Clementi G., Scapagnini U. (1986): Effects of flunarizine on experimentally-induced convulsions in animals. Functional Neurology 1: 529-532. 75. Drago F., Van Ree J.M., De Wied D. (1986): Desenkephalin-γ-endorphin restores the impaired sensitivity of hypophysectomized rats to small doses of apomorphine. European Journal of Pharmacology 128: 205-212. 74. Drago F., Bohus B., Bitetti R., Scapagnini U., van Ree J.M., de Wied D. (1986): Intracerebroventricular injection of anti-prolactin serum suppresses excessive grooming of pituitary homografted rats. Behavioral and Neural Biology 46: 99-105. 73. Drago F., Continella G., Pennisi G., Alloro MC., Calvani M., Scapagnini U. (1986): Behavioral effects of acetyl-l-carnitine in the male rat. Pharmacology Biochemistry Behavior 24: 1393-1396. 28 72. Caldwell J.D., Drago F., Prange A.J., Pedersen C.A. (1986): A comparison of grooming behavior potencies of neurohypophyseal nonapeptides. Regulatory Peptides 14: 261-271. 71. Drago F., Caldwell JD., Pedersen CA., Continella G., Scapagnini U., Prange A.J. Jr. (1986): Dopamine neurotransmission in the nucleus accumbens may be involved in oxytocin-enhanced grooming behavior of the rat. Pharmacology Biochemistry Behavior 24:1185- 1188. 70. Drago F., Continella G., Spadaro F., Cavaliere S., Scapagnini U. (1986): Behavioral effects of deprenyl in aged rats. Functional Neurology 1: 165-174. 69. Drago F., Pedersen C.A., Caldwell J.D., Prange A.J. Jr. (1986): Oxytocin potently enhances novelty-induced grooming behavior in the rat. Brain Research 368:287 295. 68. Hernandez D.E., Drago F., Mason G.A., Stanley D.A., Prange A.J. Jr. (1986): Effect of dopamine agonists and antagonists on neurotensin-induced antinociception. Pharmacology Biochemistry and Behavior 24: 425-428. 67. Brambilla F., Aguglia E., Massironi R., Maggioni M., Grillo W., Castiglioni R., Catalano M., Drago F. (1986): Neuropeptide therapies in chronic schizophrenia: TRH and vasopressin administration. Neuropsychobiology 15: 114-121. 66. Drago F., Scapagnini U. (1986): Hormonal modulation of central dopaminergic transmission. Journal of Neural Transmission suppl. 22: 47-54. 65. Patti F., Drago F., Marano P., Nicoletti F., Scapagnini U. (1986): Effect of sulpiride on chronic abstinence syndrome in addicted patients. Clinical Neuropharmacology 9: 469476. 64. Continella G., Drago F., Auditore S., Scapagnini U. (1985): Quantitative alteration of grooming behavior in aged male rats. Physiology and Behavior 35: 839-841. 63. Hernandez DE., Simons KB., Spampinato D., Peiffer RL Jr., Drago F (1985): Intracameral administration of α-MSH increases intraocular pressure in rabbits. Neuropeptides 6: 553-560. 62. Drago F., Continella G. (1985): Somatic growth in hypophysectomized pituitaryhomografted rats is promoted by prolactin. Experientia 41: 1442-1444. 61. Drago F., Kovacs G.L., Szabo G., Scapagnini U., Telegdy G. (1985): Effects of haloperidol on morphine-induced antinociception, morphine tolerance and withdrawal in hypeprolactinaemic rats. Neuropharmacology 24: 1027-1031. 60. Drago F., Continella G., Mason G.A., Hernandez D.E., Scapagnini U. (1985): Phospholipid liposomes potentiate the inhibitory effect of antidepressant drugs on immobility of rats in a despair test (constrained swim). European Journal of Pharmacology 115: 179-184. 59. Drago F., Continella G., Alloro M.C., Scapagnini U. (1985): Behavioral effects of perinatal administration of antidepressant drugs in the rat. Neurobehavioral Toxicology 29 and Teratology 7: 493-497. 58. Drago F., Scapagnini U. (1985): Side effects of drugs stimulating prolactin secretion on the behavior of male rats. Archives International de Pharmachodynamie et de Therapie 276: 271-278. 57. Drago F., Scapagnini U. (1985): Effects of endogenous hyperprolactinaemia on opiateinduced behavioral changes in rats. Brain Research 336: 215-221. 56. Drago F., Continella G., Mangano O., Canonico P.L., Bernardini R., Scapagnini U. (1985): Neuroendocrine and behavioral effects of flunarizine in young and old rats. Cephalagia 6 (suppl. 2): 125-129. 55. Drago F., Panissidi GB., Bellomio F., Dal Bello A., Aguglia E., Gorgone G. (1985): Effects of opiates and opioids on intraocular pressure of rabbits and humans. Clinical and Experimental Pharmacology and Physiology 12: 107-113. 54. Drago F., Aguglia E., Dal Bello A., Panissidi G.B., Bellomio F., Spampinato D., Gorgone G. (1985): Ocular instillation of naloxone increases intraocular pressure in morphine-addicted patients: a possible test for detecting misuse of morphine. Experientia 41: 266-267. 53. Drago F., Continella G., Conforto G., Scapagnini U. (1985): Prolactin inhibits the development of stress-induced ulcers in the rat. Life Sciences 36: 191-197. 52. Ferrara N., Bernardini R., Nicoletti F., Drago F., Matera M., Ceravolo A., Scapagnini U (1985): Prolactin influences sexual behavior during aging. Journal of Endocrinological Investigations 8 (suppl.2):23-32. 51. Drago F., Continella G., Scapagnini U. (1985): Behavioral and neurochemical changes in long-term hyperprolactinemia. Adv Biochem Psychopharmacol. 40: 47-58. 50. Kovacs G.L., Drago F., Acsai L., Tihanyi A., Scapagnini U., Telegdy G. (1984): Catecholamine utilization in specific rat brain nuclei after short-term hyperprolactinaemia. Brain Research 324: 29-34. 49. Clementi G., Drago F., Prato A., Cavaliere S., Di Benedetto A., Leone F., Scapagnini U., Rodolico G. (1984): Effects of calcitonin, parathyroid hormone and its related fragments on acquisition of active avoidance behavior. Physiology and Behavior 33: 913-916. 48. Drago F., Continella G., Alloro M.C., Auditore S., Pennisi G. (1984): Behavioral effects of arginine in male rats. Pharmacological Research Communications 16: 34-39. 47. Gerendai I., Drago F., Continella G., Scapagnini U. (1984): Effects of mastectomy and vagotomy on grooming behavior of the rat: possible involvement of prolactin. Physiology and Behavior 33: 1-4. 46. Continella G., Drago F., Amico-Roxas M., Scapagnini U. (1984): Effects of valproic acid derivatives on the acquisition of active avoidance behavior in the rat. Pharmacological Research Communications 16: 699-704. 30 45. Drago F., Caccamo G., Continella G., Scapagnini U. (1984): Amphetamine-induced analgesia does not involve brain opioids. European Journal of Pharmacology 101: 267-269. 44. Drago F., Continella G., Scapagnini U. (1984): Behavioral activity of a short chain ACTH analog. Pharmacology Biochemistry and Behavior 20: 689-695. 43. Drago F., Amir S. (1984): Effects of hyperprolactinaemia on core temperature of the rat. Brain Research Bulletin 12: 355-358. 42. Drago F. (1984): Prolactin and sexual behavior: a review. Neuroscience and Biobehavioral Reviews 8: 433-439. 41. Villardita C., Smirni P., Bozzanca L.R., Nicoletti F., Drago F. (1983): Effects of pyrimidine nucleosides and n-acetyl-glutamine on learning and memory processes in men of various ages. Acta Therapeutica 9: 407-416. 40. Villardita C., Vecchio I., Pennisi G., Nicoletti F., Drago F. (1983): Treatment of cognitive disturbances in children and elderly with a new pharmacological combination. Acta Therapeutica 9: 399-405. 39 Villardita C., Rodolico G., Cupone V., Drago F (1985): Effects of a pharmacological combination of l-glutamine., dl-phosphorylserine., l-asparagine and pyridoxine on cognitive disturbances in children. Acta Therapeutica 11: 301-308. 38. Nicoletti F., Drago F., Speciale C., Kovacs G.L., Scapagnini U. (1983): Role of prolactin-opiate interactions in the central regulation of pain threshold. Cephalalgia 3 (suppl. 1): 31-34. 37. Fekete M., Drago F., van Ree J.M., Bohus B., Wiegant V.M., de Wied D. (1983): Naltrexone-sensitive behavioral actions of the ACTH 4-9 analog (Org 2766). Life Sciences 32: 2193-2204. 36. De Kloet E.R., Drago F., Mezey E., Bohus B., de Wied D. (1983): Pituitary stalk section transiently impairs the acquisition of shuttle-box avoidance behavior. Physiology and Behavior 30: 499-502. 35. Drago F., Bohus B., Gispen W.H., Scapagnini U., de Wied D. (1983): Prolactinenhanced grooming behavior: interaction with ACTH. Brain Research 263: 277-282. 34. Drago F., Motta A., Grossi E. (1983): Intravenous maprotiline in severe and resistant primary depression: a double-blind comparison with clomipramine. Journal of International Medicinal Research 11: 78-84. 33. Drago F., Amico-Roxas M., Matera M., Bitetti R., Bellomio F., Dal Bello A., Panissidi G.B., Moro F., Scapagnini U. (1982): Effects of l-acetyl-carnitine on the electroretinographic responses in patients with central retinal artery occlusion. Acta Therapeutica 8: 201-208. 32 Drago F., Continella G., De Luca G. (1982): Effects of pyrimidine nucleosides and nacetyl-glutamine on avoidance behaviour of the rat. Acta Therapeutica 8: 337-344. 31 31. Drago F., Lo Presti L., Nardo F., Panella I., Matera M., Scapagnini U. (1982): Aromatization of testosterone by adipose tissue and sexual behavior of castrated male rats. Biology of Reproduction 27: 765-770. 30. Drago F., Wiegant V.M., Sapienza G., Aguglia E., Rapisarda V., Scapagnini U. (1982): Mianserin reduces plasma levels of beta-endorphin immunoreactivity in depressed patients. Experientia 38: 685. 29. Drago F., Bohus B., van Ree J.M., Scapagnini U., de Wied D. (1982): Behavioral responses of long-term hyperprolactinaemic rats. European Journal of Pharmacology 79: 323-327. 28. Drago F., Bohus B., Mattheij J.A.M. (1982): Endogenous hyperprolactinaemia and avoidance behaviors of the rat. Physiology and Behavior 28: 1-4. 27. Drago F., Rapisarda V., Calandra C., Filetti S., Scapagnini U. (1981): A clinical evaluation of the effects of vasopressin on memory disorders. Acta Therapeutica 7:345-352. 26. Canonico P.L., Annunziato L., Toffano G., Bernardini R., Stanzani S., Foti M., Clementi G., Drago F., Scapagnini U. (1981): In vivo and in vitro interference of phosphatidylserine liposomes on prolactin secretion in the rat. Neuroendocrinology 33: 358-362. 25. Drago F., Canonico P.L., Amico-Roxas M. (1981): Effect of suloctidil on blood viscosity in healthy volunteers after forearm occlusion. Experientia 37: 1095. 24. Drago F., Bohus B. (1981): Hyperprolactinaemia-induced excessive grooming in the rat: time course and element analysis. Behavioral and Neural Biology 33: 117-122. 23. Amico-Roxas M., Drago F., Canonico P.L., Russo A., Terranova R., Spitaleri A., Bianchi A. (1981): Plasma viscosity: relation to age, atherogenic diet and suloctidil. Pharmacological Research Communications 13: 765-767. 22. Drago F., Bohus B., Canonico P.L., Scapagnini U. (1981): Prolactin induces grooming in the rat: possible involvement of nigrostriatal dopaminergic system. Pharmacology Biochemistry and Behavior 15: 61-63. 21. Drago F., van Ree J.M., Bohus B., de Wied D. (1981): Endogenous hyperprolactinaemia enhances amphetamine- and apomorphine-induced stereotypy. European Journal of Pharmacology 72: 249-253. 20. Prato A., Clementi G., Nicoletti F., Canonico P.L., Patti F., Condorelli D.F., Di Giorgio R.M., Drago F. (1981): Possible role of prolactin in the modification of medial basal hypothalamic glutamic acid decarboxylase activity. European Journal of Pharmacology 71: 169-172. 19. Moro F., Scapagnini U., Scaletta S., Drago F. (1981): Serotonin nerve endings and regulation of pupillary diameter. Annals of Ophtalmology 1: 487-490. 18. Rampello L., Nicoletti F., Patti F., Condorelli D.F., Drago F., Maugeri S., Prestifilippo N., Patané C., Reggio A., Raffaele R. (1981): Evaluation of motor behavior in 32 conditions of hyperprolactinemia. Acta Neurologica Napoli 3: 297-301. 17. Drago F., Pellegrini-Quarantotti B., Scapagnini U., Gessa G.L. (1981): Short-term endogenous hyperprolactinaemia and sexual behavior of male rats. Physiology and Behavior 26: 277-279. 16. Drago F., Canonico P.L., Scapagnini U. (1981): Behavioral phosphatidylserine in aged rats. Neurobiology of Aging 2: 209-213. 15. Rampello L., Nicoletti F., Patti F., Condorelli D.F., Drago F., Maugeri S., Prestifilippo N., Patané C., Reggio A., Raffaele R. (1981): Evaluation of motor behavior in hyperprolactinemic conditions. Acta Neurologica Quaderni (Napoli) 42: 297-301. 14. Moro F., Drago F. (1980): Endocrine optic neuropathies. Documenta Ophthalmologica 49: 361-367. 13. Prato A., Amico-Roxas M., Canonico P.L., Drago F., Clementi G. (1980): In vitro and in vivo antiserotoninergic effects of l-isopropylnoradrenochrome-5monosemicarbazone (Divascan). Pharmacological Research Communications 12: 751756. 12 Drago F., Canonico P.L., Bitetti R., Scapagnini U. (1980): Systemic and intraventricular prolactin induces excessive grooming. European Journal of Pharmacology 65: 457-458. 11. Drago F., Amico-Roxas M., Russo A., Bianchi A., Mazzoleni G. (1980): Effect of suloctidil on plasma viscosity in rats on an atherogenic diet. Il Farmaco Edizione Pratica 35: 423-426. 10. Drago F., Bohus B., Scapagnini U., de Wied D. (1980): Sexual dimorphism in passive avoidance behavior of rats: relation to body weigth, age, shock intensity and retention interval. Physiology and Behavior 24: 1161-1164. 9. Gerendai I., Wenger T., Marchetti B., Clementi G., Prato A., Canonico P.L., Drago F., D'Agata R., Scapagnini U. (1980): Monoaminergic regulation of LHRH in the organon vasculosum of lamina terminalis (OVLT). Pharmacological Research Communications 12: 385-391. 8. Calandra C, Drago F, Filetti S. (1980): Case of memory disorder treated with vasopressin. Minerva Psichiatrica 21: 63-66. 7. De Maio D., Drago F., Nielsen P., Ascalone V., Cisternino M. (1980): Plasma concentrations of amitriptyline during single nightly and thrice daily administration. Cross-over study. Arzneimittelforschung. 30: 335-337. 6. Drago F., Gorgone G., Spina F., Panissidi G.B., Dal Bello A., Moro F., Scapagnini U. (1980): Opiate receptors in the rabbit iris. Naunyn-Schmiedeberg's Archives of Pharmacology 315: 1-4. 5. Moro F., Scapagnini U., Gorgone G., Reina R., Scaletta S., Drago F. (1979): Chronic degeneration of aminergic nerve endings and blood-aqueous barrier. Albrecht Von effects of 33 Graefes Archives of Clinical and Experimental Ophthalmology 209: 225-230. 4. Matera M., Amico-Roxas M., Fiore L., Prato A., Clementi G., Corsello S., Drago F., Guarcello V. (1979): Influence of hematoporphyrin on the tonic or phasic secretion of prolactin. La Clinica Terapeutica 88: 183-193. 3. Drago F., Di Dino G., Lo Presti L. (1979): Rare anomaly of the flexor carpi ulnaris associated with absence of the palmaris longus. Archivio Italiano di Anatomia ed Embriologia 84: 71-80. 2. Bianchi A., Drago F., Canonico P.L., Guarcello V., Carpiniello B., Scapagnini U. (1978): Neuroendocrine effects of bromperidol. Acta Psychiatrica Belgica 78: 69-82. 1. Amico-Roxas M., Matera M., Cannavà N., Drago F. (1977): Central muscle-relaxant activity of a new benzodiazepine derivative: prazepam. La Clinica Terapeutica 31: 159-165.