Heated Tobacco - Opportunity or Distraction?

Heated Tobacco
Opportunity or Distraction?
FDA Workshop on E-Vapour Products
Dr
Stephen
Stotesbury
Steve
Stotesbury
Head of Regulatory Science, Imperial Tobacco Limited, Bristol, UK
10 March 2015
Emissions from Heated Tobacco
and E-Vapour
HPHCs: Percentage relative to Cigarette smoke*

EVP and Heated Tobacco
both produce much lower
emissions relative to
cigarettes
16
14
Formaldehyde
12
Acetaldehyde



Products of combustion
found in output from
Heated Tobacco
EVP emissions
substantially different to
and less than cigarette or
Heated Tobacco
E-Vapour is not smoke
Acrolein
10
Crotonaldehyde
CO
8
Benzene
Toluene
6
B[a]P
Acrylonitrile
4
NNK
NNN
2
0
Heated Tobacco - iQOS
EVP - Puritane 16mg
* 55ml puff every 30 seconds. 10 puffs each from EVP and Heated Tobacco.
Each HPHC presented as a percentage relative to quantity measured in cigarette smoke emissions (Marlboro Gold – Germany)
2
Impact on Indoor Air-Quality
Exhaled Air – PTR-MS study

Substantially less chemicals from
E-vapour

E-vapour profile similar to
Nicorette Inhalator®

Exhalate from Heated Tobacco
qualitatively similar to cigarette
smoke
Real-time analysis of exhaled breath following the use of a range of nicotine delivery products by PTR-MS: proof of concept study, O’ Connell,
Burseg, Breiev, Colard and Pritchard http://www.imperialtobaccoscience.com/files/pdf/environmentaltobaccosmoke/Realtime_analysis_of_exhaled_breath_following_the_use_of_a_range_of_nicotine_delivery_products.pdf
3
Summary

Claims for Heated Tobacco need to be critically evaluated

Heated tobacco offers potential for reduced exposure – but
does not eliminate exposure to smoke

E-vapour has greatest potential for harm reduction
4